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Volume of Plasma Cleared given Elimination Half Life Calculator

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✖The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.ⓘ Volume of Distribution [V_d]			+10% -10%
✖Elimination Half Life is the time required for the concentration of the drug to reach half of its original value.ⓘ Elimination Half Life [t_b/2]			+10% -10%

✖The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.ⓘ Volume of Plasma Cleared given Elimination Half Life [CL]

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Volume of Plasma Cleared given Elimination Half Life Solution

STEP 0: Pre-Calculation Summary

Formula Used

Volume of Plasma Cleared = (ln(2)*Volume of Distribution)/Elimination Half Life
CL = (ln(2)*V_d)/t_b/2
This formula uses 1 Functions, 3 Variables

Functions Used

ln - The natural logarithm, also known as the logarithm to the base e, is the inverse function of the natural exponential function., ln(Number)

Variables Used

Volume of Plasma Cleared - (Measured in Cubic Meter per Second) - The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.
Volume of Distribution - (Measured in Cubic Meter) - The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.
Elimination Half Life - (Measured in Second) - Elimination Half Life is the time required for the concentration of the drug to reach half of its original value.

STEP 1: Convert Input(s) to Base Unit

Volume of Distribution: 9 Liter --> 0.009 Cubic Meter (Check conversion here)
Elimination Half Life: 12 Second --> 12 Second No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

CL = (ln(2)*V_d)/t_b/2 --> (ln(2)*0.009)/12

Evaluating ... ...

CL = 0.000519860385419959

STEP 3: Convert Result to Output's Unit

0.000519860385419959 Cubic Meter per Second -->0.519860385419959 Liter per Second (Check conversion here)

FINAL ANSWER

0.519860385419959 ≈ 0.51986 Liter per Second <-- Volume of Plasma Cleared

(Calculation completed in 00.004 seconds)

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< Volume of plasma cleared Calculators

Volume of Plasma Cleared given Elimination Half Life

LaTeX Go Volume of Plasma Cleared = (ln(2)*Volume of Distribution)/Elimination Half Life

Volume of Plasma Cleared of Drug given Rate at which Drug is Removed

LaTeX Go Volume of Plasma Cleared = Elimination Rate Constant*Volume of Distribution

Volume of Plasma Cleared given Rate of Infusion

LaTeX Go Volume of Plasma Cleared = Rate of Infusion/Concentration of Drug

Volume of Plasma Cleared given Area under Curve

LaTeX Go Volume of Plasma Cleared = Dose/Area Under Curve

Volume of Plasma Cleared given Elimination Half Life Formula

LaTeX Go

Volume of Plasma Cleared = (ln(2)*Volume of Distribution)/Elimination Half Life
CL = (ln(2)*V_d)/t_b/2

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Volume of Plasma Cleared given Elimination Half Life?

Volume of Plasma Cleared given Elimination Half Life calculator uses Volume of Plasma Cleared = (ln(2)*Volume of Distribution)/Elimination Half Life to calculate the Volume of Plasma Cleared, The Volume of plasma cleared given elimination half life formula is defined as the direct relation with the apparent volume in which a drug is distributed and an inverse relationship with the time required for the concentration of the drug to reach half of its original value. Volume of Plasma Cleared is denoted by CL symbol.

How to calculate Volume of Plasma Cleared given Elimination Half Life using this online calculator? To use this online calculator for Volume of Plasma Cleared given Elimination Half Life, enter Volume of Distribution (V_d) & Elimination Half Life (t_b/2) and hit the calculate button. Here is how the Volume of Plasma Cleared given Elimination Half Life calculation can be explained with given input values -> 519.8604 = (ln(2)*0.009)/12.

FAQ

What is Volume of Plasma Cleared given Elimination Half Life?

The Volume of plasma cleared given elimination half life formula is defined as the direct relation with the apparent volume in which a drug is distributed and an inverse relationship with the time required for the concentration of the drug to reach half of its original value and is represented as CL = (ln(2)*V_d)/t_b/2 or Volume of Plasma Cleared = (ln(2)*Volume of Distribution)/Elimination Half Life. The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body & Elimination Half Life is the time required for the concentration of the drug to reach half of its original value.

How to calculate Volume of Plasma Cleared given Elimination Half Life?

The Volume of plasma cleared given elimination half life formula is defined as the direct relation with the apparent volume in which a drug is distributed and an inverse relationship with the time required for the concentration of the drug to reach half of its original value is calculated using Volume of Plasma Cleared = (ln(2)*Volume of Distribution)/Elimination Half Life. To calculate Volume of Plasma Cleared given Elimination Half Life, you need Volume of Distribution (V_d) & Elimination Half Life (t_b/2). With our tool, you need to enter the respective value for Volume of Distribution & Elimination Half Life and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Volume of Plasma Cleared?

In this formula, Volume of Plasma Cleared uses Volume of Distribution & Elimination Half Life. We can use 3 other way(s) to calculate the same, which is/are as follows -

Volume of Plasma Cleared = Elimination Rate Constant*Volume of Distribution
Volume of Plasma Cleared = Rate of Infusion/Concentration of Drug
Volume of Plasma Cleared = Dose/Area Under Curve

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