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Volume of Dose Distribution given Loading Dose Calculator

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✖The Loading Dose is the initial dose of a drug that is administered to achieve a desired plasma concentration.ⓘ Loading Dose [LD]			+10% -10%
✖The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.ⓘ Bioavailability Of drug dose [F%]			+10% -10%
✖The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.ⓘ Target Plasma Concentration [C_p]			+10% -10%

✖The Volume of distribution dose is used to describe the apparent distribution of a drug in the body relative to its concentration in the plasma.ⓘ Volume of Dose Distribution given Loading Dose [V_d]

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Volume of Dose Distribution given Loading Dose Solution

STEP 0: Pre-Calculation Summary

Formula Used

Volume Of Distribution dose = (Loading Dose*Bioavailability Of drug dose)/Target Plasma Concentration
V_d = (LD*F%)/C_p
This formula uses 4 Variables

Variables Used

Volume Of Distribution dose - (Measured in Cubic Meter) - The Volume of distribution dose is used to describe the apparent distribution of a drug in the body relative to its concentration in the plasma.
Loading Dose - (Measured in Kilogram) - The Loading Dose is the initial dose of a drug that is administered to achieve a desired plasma concentration.
Bioavailability Of drug dose - The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.
Target Plasma Concentration - (Measured in Kilogram per Cubic Meter) - The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.

STEP 1: Convert Input(s) to Base Unit

Loading Dose: 50 Milligram --> 5E-05 Kilogram (Check conversion here)
Bioavailability Of drug dose: 0.9 --> No Conversion Required
Target Plasma Concentration: 30 Milligram per Liter --> 0.03 Kilogram per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

V_d = (LD*F%)/C_p --> (5E-05*0.9)/0.03

Evaluating ... ...

V_d = 0.0015

STEP 3: Convert Result to Output's Unit

0.0015 Cubic Meter -->1.5 Liter (Check conversion here)

FINAL ANSWER

1.5 Liter <-- Volume Of Distribution dose

(Calculation completed in 00.004 seconds)

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University of Calcutta (C.U), Kolkata

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Volume of Dose Distribution given Loading Dose Formula

LaTeX Go

Volume Of Distribution dose = (Loading Dose*Bioavailability Of drug dose)/Target Plasma Concentration
V_d = (LD*F%)/C_p

How does the loading dose achieve quick clinical response?

Loading doses are a means to quicks achieve therapeutic drug concentrations or prompt an immediate clinical response. Loading doses are larger than maintenance doses and are usually administered as a single bolus, although some drugs (eg, amiodarone or digoxin) may require multiple loading doses administered over several hours to days.[1] An intravenous loading dose of phenytoin, on the other hand, should be administered as a single dose. Medications with shorter half-lives (eg, heparin for treating pulmonary embolism) may also require a loading dose to achieve their therapeutic effect immediately.

How to Calculate Volume of Dose Distribution given Loading Dose?

Volume of Dose Distribution given Loading Dose calculator uses Volume Of Distribution dose = (Loading Dose*Bioavailability Of drug dose)/Target Plasma Concentration to calculate the Volume Of Distribution dose, The Volume of Dose Distribution given Loading Dose formula is defined as the ratio of the product of the loading dose and bioavailability of drug dose to the target plasma concentration. Volume Of Distribution dose is denoted by V_d symbol.

How to calculate Volume of Dose Distribution given Loading Dose using this online calculator? To use this online calculator for Volume of Dose Distribution given Loading Dose, enter Loading Dose (LD), Bioavailability Of drug dose (F%) & Target Plasma Concentration (C_p) and hit the calculate button. Here is how the Volume of Dose Distribution given Loading Dose calculation can be explained with given input values -> 4.5E+10 = (5E-05*0.9)/0.03.

FAQ

What is Volume of Dose Distribution given Loading Dose?

The Volume of Dose Distribution given Loading Dose formula is defined as the ratio of the product of the loading dose and bioavailability of drug dose to the target plasma concentration and is represented as V_d = (LD*F%)/C_p or Volume Of Distribution dose = (Loading Dose*Bioavailability Of drug dose)/Target Plasma Concentration. The Loading Dose is the initial dose of a drug that is administered to achieve a desired plasma concentration, The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form & The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.

How to calculate Volume of Dose Distribution given Loading Dose?

The Volume of Dose Distribution given Loading Dose formula is defined as the ratio of the product of the loading dose and bioavailability of drug dose to the target plasma concentration is calculated using Volume Of Distribution dose = (Loading Dose*Bioavailability Of drug dose)/Target Plasma Concentration. To calculate Volume of Dose Distribution given Loading Dose, you need Loading Dose (LD), Bioavailability Of drug dose (F%) & Target Plasma Concentration (C_p). With our tool, you need to enter the respective value for Loading Dose, Bioavailability Of drug dose & Target Plasma Concentration and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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