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Target Plasma Concentration given Maintenance Dose Calculator

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✖The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.ⓘ Maintenance Dose [MD]			+10% -10%
✖The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.ⓘ Bioavailability Of drug dose [F%]			+10% -10%
✖Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.ⓘ Drug Clearance [CL_drug]			+10% -10%

✖The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.ⓘ Target Plasma Concentration given Maintenance Dose [C_p]

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Target Plasma Concentration given Maintenance Dose Solution

STEP 0: Pre-Calculation Summary

Formula Used

Target Plasma Concentration = (Maintenance Dose*Bioavailability Of drug dose/Drug Clearance)
C_p = (MD*F%/CL_drug)
This formula uses 4 Variables

Variables Used

Target Plasma Concentration - (Measured in Kilogram per Cubic Meter) - The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.
Maintenance Dose - (Measured in Kilogram per Second) - The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.
Bioavailability Of drug dose - The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.
Drug Clearance - (Measured in Cubic Meter per Second) - Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.

STEP 1: Convert Input(s) to Base Unit

Maintenance Dose: 70 Milligram per Hour --> 1.94444444444444E-08 Kilogram per Second (Check conversion here)
Bioavailability Of drug dose: 0.9 --> No Conversion Required
Drug Clearance: 2 Cubic Meter per Second --> 2 Cubic Meter per Second No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

C_p = (MD*F%/CL_drug) --> (1.94444444444444E-08*0.9/2)

Evaluating ... ...

C_p = 8.74999999999998E-09

STEP 3: Convert Result to Output's Unit

8.74999999999998E-09 Kilogram per Cubic Meter -->8.74999999999998E-06 Milligram per Liter (Check conversion here)

FINAL ANSWER

8.74999999999998E-06 ≈ 8.7E-6 Milligram per Liter <-- Target Plasma Concentration

(Calculation completed in 00.004 seconds)

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Created by Ritacheta Sen

University of Calcutta (C.U), Kolkata

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National University of Judicial Science (NUJS), Kolkata

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Target Plasma Concentration given Maintenance Dose Formula

LaTeX Go

Target Plasma Concentration = (Maintenance Dose*Bioavailability Of drug dose/Drug Clearance)
C_p = (MD*F%/CL_drug)

How does loading dose useful for drugs ?

A loading dose is most useful for drugs that are eliminated from the body relatively slowly. Such drugs need only a low maintenance dose in order to keep the amount of the drug in the body at the appropriate level, but this also means that, without an initial higher dose, it would take a long time for the amount of the drug in the body to reach that level.

How to Calculate Target Plasma Concentration given Maintenance Dose?

Target Plasma Concentration given Maintenance Dose calculator uses Target Plasma Concentration = (Maintenance Dose*Bioavailability Of drug dose/Drug Clearance) to calculate the Target Plasma Concentration, The Target Plasma Concentration given Maintenance Dose formula is defined as the ratio of the product of the maintenance dose and bioavailaility of drug to the clearance of drug. Target Plasma Concentration is denoted by C_p symbol.

How to calculate Target Plasma Concentration given Maintenance Dose using this online calculator? To use this online calculator for Target Plasma Concentration given Maintenance Dose, enter Maintenance Dose (MD), Bioavailability Of drug dose (F%) & Drug Clearance (CL_drug) and hit the calculate button. Here is how the Target Plasma Concentration given Maintenance Dose calculation can be explained with given input values -> 0.00875 = (1.94444444444444E-08*0.9/2).

FAQ

What is Target Plasma Concentration given Maintenance Dose?

The Target Plasma Concentration given Maintenance Dose formula is defined as the ratio of the product of the maintenance dose and bioavailaility of drug to the clearance of drug and is represented as C_p = (MD*F%/CL_drug) or Target Plasma Concentration = (Maintenance Dose*Bioavailability Of drug dose/Drug Clearance). The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration, The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form & Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.

How to calculate Target Plasma Concentration given Maintenance Dose?

The Target Plasma Concentration given Maintenance Dose formula is defined as the ratio of the product of the maintenance dose and bioavailaility of drug to the clearance of drug is calculated using Target Plasma Concentration = (Maintenance Dose*Bioavailability Of drug dose/Drug Clearance). To calculate Target Plasma Concentration given Maintenance Dose, you need Maintenance Dose (MD), Bioavailability Of drug dose (F%) & Drug Clearance (CL_drug). With our tool, you need to enter the respective value for Maintenance Dose, Bioavailability Of drug dose & Drug Clearance and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Target Plasma Concentration?

In this formula, Target Plasma Concentration uses Maintenance Dose, Bioavailability Of drug dose & Drug Clearance. We can use 2 other way(s) to calculate the same, which is/are as follows -

Target Plasma Concentration = (Revised Dose*Measured Steady State Concentration Plasma)/Previous Rate of Dose
Target Plasma Concentration = (Loading Dose*Bioavailability Of drug dose)/Volume Of Distribution dose

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