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Renal Clearance of Drug Calculator

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✖Drug Amount Excreted Unchanged in Urine is the concentration of drug excreted through urine.ⓘ Drug Amount Excreted Unchanged in Urine [A_u]			+10% -10%
✖Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.ⓘ Area Under Curve [AUC]			+10% -10%

✖Renal Clearance is a measure of kidney transport in units of volume of plasma per unit time.ⓘ Renal Clearance of Drug [CL_r]

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Formula

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Renal Clearance of Drug

Formula

CL r = \frac{A u}{AUC}

Example

0.372727 mL/min = \frac{8.2 μg/L}{1.320 mol*s/L}

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Renal Clearance of Drug Solution

STEP 0: Pre-Calculation Summary

Formula Used

Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve
CL_r = A_u/AUC
This formula uses 3 Variables

Variables Used

Renal Clearance - (Measured in Cubic Meter per Second) - Renal Clearance is a measure of kidney transport in units of volume of plasma per unit time.
Drug Amount Excreted Unchanged in Urine - (Measured in Kilogram per Cubic Meter) - Drug Amount Excreted Unchanged in Urine is the concentration of drug excreted through urine.
Area Under Curve - (Measured in Mole Second per Cubic Meter) - Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.

STEP 1: Convert Input(s) to Base Unit

Drug Amount Excreted Unchanged in Urine: 8.2 Microgram per Liter --> 8.2E-06 Kilogram per Cubic Meter (Check conversion here)
Area Under Curve: 1.32 Mole Second per Liter --> 1320 Mole Second per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

CL_r = A_u/AUC --> 8.2E-06/1320

Evaluating ... ...

CL_r = 6.21212121212121E-09

STEP 3: Convert Result to Output's Unit

6.21212121212121E-09 Cubic Meter per Second -->0.372727272727273 Milliliter per Minute (Check conversion here)

FINAL ANSWER

0.372727272727273 ≈ 0.372727 Milliliter per Minute <-- Renal Clearance

(Calculation completed in 00.004 seconds)

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National University of Judicial Science (NUJS), Kolkata

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< Drug Content Calculators

Rate of Infusion of Drug

Go Rate of Infusion = Volume of Plasma Cleared*Concentration of Drug

Absorption Half-Life of Drug

Go Absorption Half Life = ln(2)/Absorption Rate Constant

Drug Rate Entering Body

Go Absorption Rate Constant = ln(2)/Absorption Half Life

Apparent Volume of Drug Distribution

Go Volume of Distribution = Dose/Concentration of Drug

Renal Clearance of Drug Formula

Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve
CL_r = A_u/AUC

What is Pharmacokinetics ?

Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabolism, and excretion. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient.

How to Calculate Renal Clearance of Drug?

Renal Clearance of Drug calculator uses Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve to calculate the Renal Clearance, The Renal Clearance of Drug formula is defined as a measure of kidney transport in units of volume of plasma per unit time. The volume of plasma measured is that volume for which a given substance (e.g., urea or drugs) is completely removed per minute. Renal Clearance is denoted by CL_r symbol.

How to calculate Renal Clearance of Drug using this online calculator? To use this online calculator for Renal Clearance of Drug, enter Drug Amount Excreted Unchanged in Urine (A_u) & Area Under Curve (AUC) and hit the calculate button. Here is how the Renal Clearance of Drug calculation can be explained with given input values -> 2.2E+7 = 8.2E-06/1320.

FAQ

What is Renal Clearance of Drug?

The Renal Clearance of Drug formula is defined as a measure of kidney transport in units of volume of plasma per unit time. The volume of plasma measured is that volume for which a given substance (e.g., urea or drugs) is completely removed per minute and is represented as CL_r = A_u/AUC or Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve. Drug Amount Excreted Unchanged in Urine is the concentration of drug excreted through urine & Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.

How to calculate Renal Clearance of Drug?

The Renal Clearance of Drug formula is defined as a measure of kidney transport in units of volume of plasma per unit time. The volume of plasma measured is that volume for which a given substance (e.g., urea or drugs) is completely removed per minute is calculated using Renal Clearance = Drug Amount Excreted Unchanged in Urine/Area Under Curve. To calculate Renal Clearance of Drug, you need Drug Amount Excreted Unchanged in Urine (A_u) & Area Under Curve (AUC). With our tool, you need to enter the respective value for Drug Amount Excreted Unchanged in Urine & Area Under Curve and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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