What is competitive Inhibition?
In competitive inhibition, the substrate and inhibitor cannot bind to the enzyme at the same time, as shown in the figure on the right. This usually results from the inhibitor having an affinity for the active site of an enzyme where the substrate also binds; the substrate and inhibitor compete for access to the enzyme's active site. This type of inhibition can be overcome by sufficiently high concentrations of substrate (Vmax remains constant), i.e., by out-competing the inhibitor. However, the apparent Km will increase as it takes a higher concentration of the substrate to reach the Km point, or half the Vmax. Competitive inhibitors are often similar in structure to the real substrate.
How to Calculate Rate Constant given Maximum Rate and Initial Enzyme Concentration?
Rate Constant given Maximum Rate and Initial Enzyme Concentration calculator uses Final Rate Constant = Maximum Rate/Initial Enzyme Concentration to calculate the Final Rate Constant, The Rate constant given maximum rate and initial enzyme concentration formula is defined as the ratio of the maximum rate of the system to the initial enzyme concentration. Final Rate Constant is denoted by k2 symbol.
How to calculate Rate Constant given Maximum Rate and Initial Enzyme Concentration using this online calculator? To use this online calculator for Rate Constant given Maximum Rate and Initial Enzyme Concentration, enter Maximum Rate (Vmax) & Initial Enzyme Concentration ([E0]) and hit the calculate button. Here is how the Rate Constant given Maximum Rate and Initial Enzyme Concentration calculation can be explained with given input values -> 0.4 = 40000/100000.