What is Pharmacokinetics?
Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.
How to Calculate Plasma Volume of Drug given Apparent Volume?
Plasma Volume of Drug given Apparent Volume calculator uses Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue)) to calculate the Plasma Volume, The Plasma volume of drug given apparent volume formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue. Plasma Volume is denoted by VP symbol.
How to calculate Plasma Volume of Drug given Apparent Volume using this online calculator? To use this online calculator for Plasma Volume of Drug given Apparent Volume, enter Volume of Distribution (Vd), Apparent Tissue Volume (VT), Fraction Unbound in Plasma (fu) & Fraction Unbound in Tissue (fut) and hit the calculate button. Here is how the Plasma Volume of Drug given Apparent Volume calculation can be explained with given input values -> 4050 = 0.009-(0.0035*(0.99/0.7)).