HCF of two numbers

Peak through Fluctuation Calculator

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✖Peak Plasma Concentration is the maximum concentration of a drug after administration.ⓘ Peak Plasma Concentration [C_max]			+10% -10%
✖Lowest Plasma Concentration is the minimum concentration that a drug reaches before the next dose is administered.ⓘ Lowest Plasma Concentration [C_min]			+10% -10%
✖Average Plasma Concentration is the average concentration of the drug after administration and before the next dose is administered.ⓘ Average Plasma Concentration [C_av]			+10% -10%

✖Peak Through Fluctuation is defined as the fluctuation within one dosing interval at a steady state.ⓘ Peak through Fluctuation [%PTF]

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Peak through Fluctuation Solution

STEP 0: Pre-Calculation Summary

Formula Used

Peak Through Fluctuation = (Peak Plasma Concentration-Lowest Plasma Concentration)/Average Plasma Concentration
%PTF = (C_max-C_min)/C_av
This formula uses 4 Variables

Variables Used

Peak Through Fluctuation - Peak Through Fluctuation is defined as the fluctuation within one dosing interval at a steady state.
Peak Plasma Concentration - (Measured in Mole per Cubic Meter) - Peak Plasma Concentration is the maximum concentration of a drug after administration.
Lowest Plasma Concentration - (Measured in Mole per Cubic Meter) - Lowest Plasma Concentration is the minimum concentration that a drug reaches before the next dose is administered.
Average Plasma Concentration - (Measured in Mole per Cubic Meter) - Average Plasma Concentration is the average concentration of the drug after administration and before the next dose is administered.

STEP 1: Convert Input(s) to Base Unit

Peak Plasma Concentration: 60.9 Mole per Liter --> 60900 Mole per Cubic Meter (Check conversion here)
Lowest Plasma Concentration: 27.7 Mole per Liter --> 27700 Mole per Cubic Meter (Check conversion here)
Average Plasma Concentration: 20 Mole per Liter --> 20000 Mole per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

%PTF = (C_max-C_min)/C_av --> (60900-27700)/20000

Evaluating ... ...

%PTF = 1.66

STEP 3: Convert Result to Output's Unit

1.66 --> No Conversion Required

FINAL ANSWER

1.66 <-- Peak Through Fluctuation

(Calculation completed in 00.004 seconds)

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Created by Prashant Singh

K J Somaiya College of science (K J Somaiya), Mumbai

Prashant Singh has created this Calculator and 700+ more calculators!

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Peak Plasma Concentration Given Peak through Fluctuation

LaTeX Go Peak Plasma Concentration = (Peak Through Fluctuation*Average Plasma Concentration)+Lowest Plasma Concentration

Peak through Fluctuation

LaTeX Go Peak Through Fluctuation = (Peak Plasma Concentration-Lowest Plasma Concentration)/Average Plasma Concentration

Peak through Fluctuation Formula

LaTeX Go

Peak Through Fluctuation = (Peak Plasma Concentration-Lowest Plasma Concentration)/Average Plasma Concentration
%PTF = (C_max-C_min)/C_av

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Peak through Fluctuation?

Peak through Fluctuation calculator uses Peak Through Fluctuation = (Peak Plasma Concentration-Lowest Plasma Concentration)/Average Plasma Concentration to calculate the Peak Through Fluctuation, The Peak through Fluctuation formula is defined as the subtraction of minimum plasma concentration of drug from maximum plasma concentration of drug per average plasma concentration of drugs. Peak Through Fluctuation is denoted by %PTF symbol.

How to calculate Peak through Fluctuation using this online calculator? To use this online calculator for Peak through Fluctuation, enter Peak Plasma Concentration (C_max), Lowest Plasma Concentration (C_min) & Average Plasma Concentration (C_av) and hit the calculate button. Here is how the Peak through Fluctuation calculation can be explained with given input values -> 1.66 = (60900-27700)/20000.

FAQ

What is Peak through Fluctuation?

The Peak through Fluctuation formula is defined as the subtraction of minimum plasma concentration of drug from maximum plasma concentration of drug per average plasma concentration of drugs and is represented as %PTF = (C_max-C_min)/C_av or Peak Through Fluctuation = (Peak Plasma Concentration-Lowest Plasma Concentration)/Average Plasma Concentration. Peak Plasma Concentration is the maximum concentration of a drug after administration, Lowest Plasma Concentration is the minimum concentration that a drug reaches before the next dose is administered & Average Plasma Concentration is the average concentration of the drug after administration and before the next dose is administered.

How to calculate Peak through Fluctuation?

The Peak through Fluctuation formula is defined as the subtraction of minimum plasma concentration of drug from maximum plasma concentration of drug per average plasma concentration of drugs is calculated using Peak Through Fluctuation = (Peak Plasma Concentration-Lowest Plasma Concentration)/Average Plasma Concentration. To calculate Peak through Fluctuation, you need Peak Plasma Concentration (C_max), Lowest Plasma Concentration (C_min) & Average Plasma Concentration (C_av). With our tool, you need to enter the respective value for Peak Plasma Concentration, Lowest Plasma Concentration & Average Plasma Concentration and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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