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Median Lethal Dose using Therapeutic Index Calculator

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✖The Median Effective Dose represents the dose at which 50% of the population exhibits the desired therapeutic effect.ⓘ Median Effective Dose [ED50]			+10% -10%
✖The Therapeutic Index measure that reflects the safety of a drug by comparing its therapeutic dose (effective dose) to its toxic dose.ⓘ Therapeutic Index [TI]			+10% -10%

✖The Median Lethal Dose which represents the dose at which 50% of the population exhibits toxic effects or dies.ⓘ Median Lethal Dose using Therapeutic Index [LD50]

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Median Lethal Dose using Therapeutic Index Solution

STEP 0: Pre-Calculation Summary

Formula Used

Median Lethal Dose = (Median Effective Dose*Therapeutic Index)
LD50 = (ED50*TI)
This formula uses 3 Variables

Variables Used

Median Lethal Dose - (Measured in Kilogram) - The Median Lethal Dose which represents the dose at which 50% of the population exhibits toxic effects or dies.
Median Effective Dose - (Measured in Kilogram) - The Median Effective Dose represents the dose at which 50% of the population exhibits the desired therapeutic effect.
Therapeutic Index - The Therapeutic Index measure that reflects the safety of a drug by comparing its therapeutic dose (effective dose) to its toxic dose.

STEP 1: Convert Input(s) to Base Unit

Median Effective Dose: 20 Milligram --> 2E-05 Kilogram (Check conversion here)
Therapeutic Index: 8 --> No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

LD50 = (ED50*TI) --> (2E-05*8)

Evaluating ... ...

LD50 = 0.00016

STEP 3: Convert Result to Output's Unit

0.00016 Kilogram -->160 Milligram (Check conversion here)

FINAL ANSWER

160 Milligram <-- Median Lethal Dose

(Calculation completed in 00.020 seconds)

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Median Lethal Dose using Therapeutic Index Formula

LaTeX Go

Median Lethal Dose = (Median Effective Dose*Therapeutic Index)
LD50 = (ED50*TI)

What can mislead to a drug's safety ?

The use of the ED50 and TD50 doses to derive the TI may be misleading about a drug's safety, depending on the slope of the dose-response curves for therapeutic and toxic effects. To overcome this deficiency, toxicologists often use another term to denote the safety of a drug: the Margin of Safety.

How to Calculate Median Lethal Dose using Therapeutic Index?

Median Lethal Dose using Therapeutic Index calculator uses Median Lethal Dose = (Median Effective Dose*Therapeutic Index) to calculate the Median Lethal Dose, The Median Lethal Dose Using Therapeutic Index formula is defined as the product of the dose needed for the therapeutic response and therapeutic index. Median Lethal Dose is denoted by LD50 symbol.

How to calculate Median Lethal Dose using Therapeutic Index using this online calculator? To use this online calculator for Median Lethal Dose using Therapeutic Index, enter Median Effective Dose (ED50) & Therapeutic Index (TI) and hit the calculate button. Here is how the Median Lethal Dose using Therapeutic Index calculation can be explained with given input values -> 1.6E+8 = (2E-05*8).

FAQ

What is Median Lethal Dose using Therapeutic Index?

The Median Lethal Dose Using Therapeutic Index formula is defined as the product of the dose needed for the therapeutic response and therapeutic index and is represented as LD50 = (ED50*TI) or Median Lethal Dose = (Median Effective Dose*Therapeutic Index). The Median Effective Dose represents the dose at which 50% of the population exhibits the desired therapeutic effect & The Therapeutic Index measure that reflects the safety of a drug by comparing its therapeutic dose (effective dose) to its toxic dose.

How to calculate Median Lethal Dose using Therapeutic Index?

The Median Lethal Dose Using Therapeutic Index formula is defined as the product of the dose needed for the therapeutic response and therapeutic index is calculated using Median Lethal Dose = (Median Effective Dose*Therapeutic Index). To calculate Median Lethal Dose using Therapeutic Index, you need Median Effective Dose (ED50) & Therapeutic Index (TI). With our tool, you need to enter the respective value for Median Effective Dose & Therapeutic Index and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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