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Maintenance Dose Calculator

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✖Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.ⓘ Drug Clearance [CL_drug]			+10% -10%
✖The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.ⓘ Target Plasma Concentration [C_p]			+10% -10%
✖The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.ⓘ Bioavailability Of drug dose [F%]			+10% -10%

✖The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.ⓘ Maintenance Dose [MD]

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Maintenance Dose Solution

STEP 0: Pre-Calculation Summary

Formula Used

Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose
MD = CL_drug*C_p/F%
This formula uses 4 Variables

Variables Used

Maintenance Dose - (Measured in Kilogram per Second) - The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.
Drug Clearance - (Measured in Cubic Meter per Second) - Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.
Target Plasma Concentration - (Measured in Kilogram per Cubic Meter) - The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.
Bioavailability Of drug dose - The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.

STEP 1: Convert Input(s) to Base Unit

Drug Clearance: 2 Cubic Meter per Second --> 2 Cubic Meter per Second No Conversion Required
Target Plasma Concentration: 30 Milligram per Liter --> 0.03 Kilogram per Cubic Meter (Check conversion here)
Bioavailability Of drug dose: 0.9 --> No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

MD = CL_drug*C_p/F% --> 2*0.03/0.9

Evaluating ... ...

MD = 0.0666666666666667

STEP 3: Convert Result to Output's Unit

0.0666666666666667 Kilogram per Second -->240000000 Milligram per Hour (Check conversion here)

FINAL ANSWER

240000000 ≈ 2.4E+8 Milligram per Hour <-- Maintenance Dose

(Calculation completed in 00.004 seconds)

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Created by Ritacheta Sen

University of Calcutta (C.U), Kolkata

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National University of Judicial Science (NUJS), Kolkata

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Maintenance Dose Formula

LaTeX Go

Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose
MD = CL_drug*C_p/F%

What is the maintenance dose for allergic reactions to stinging and biting?

The recommended maintenance dose is 100 μg of the venom, for both children and adults. This maintenance dose is equivalent to approximately two bee stings or several vespid stings. A higher dose (e.g., 200 μg) is recommended when systemic reactions occur after re-exposure to a field sting or a sting challenge. In highly exposed subjects such as beekeepers or professional gardeners a maintenance dose of 200 μg is advised.

How to Calculate Maintenance Dose?

Maintenance Dose calculator uses Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose to calculate the Maintenance Dose, The Maintenance Dose formula is defined as the dose of a drug that is administered on a regular basis to maintain a desired plasma concentration. Maintenance Dose is denoted by MD symbol.

How to calculate Maintenance Dose using this online calculator? To use this online calculator for Maintenance Dose, enter Drug Clearance (CL_drug), Target Plasma Concentration (C_p) & Bioavailability Of drug dose (F%) and hit the calculate button. Here is how the Maintenance Dose calculation can be explained with given input values -> 8.6E+17 = 2*0.03/0.9.

FAQ

What is Maintenance Dose?

The Maintenance Dose formula is defined as the dose of a drug that is administered on a regular basis to maintain a desired plasma concentration and is represented as MD = CL_drug*C_p/F% or Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose. Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation, The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration & The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.

How to calculate Maintenance Dose?

The Maintenance Dose formula is defined as the dose of a drug that is administered on a regular basis to maintain a desired plasma concentration is calculated using Maintenance Dose = Drug Clearance*Target Plasma Concentration/Bioavailability Of drug dose. To calculate Maintenance Dose, you need Drug Clearance (CL_drug), Target Plasma Concentration (C_p) & Bioavailability Of drug dose (F%). With our tool, you need to enter the respective value for Drug Clearance, Target Plasma Concentration & Bioavailability Of drug dose and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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