Initial Reaction Rate given Catalytic Rate Constant and Dissociation Rate Constants Calculator

✖The Catalytic Rate Constant is defined as the rate constant for conversion of the enzyme-substrate complex to enzyme and product.ⓘ Catalytic Rate Constant [k_cat]			+10% -10%
✖The Initial Enzyme Concentration is defined as the concentration of enzyme at the start of the reaction.ⓘ Initial Enzyme Concentration [[E₀]]			+10% -10%
✖The Substrate Concentration is the number of moles of substrate per liter solution.ⓘ Substrate Concentration [S]			+10% -10%
✖The Dissociation Rate Constant is the ratio of reverse and forward rate constant.ⓘ Dissociation Rate Constant [K_D]			+10% -10%

✖The Initial Reaction Rate is defined as the initial speed at which a chemical reaction takes place.ⓘ Initial Reaction Rate given Catalytic Rate Constant and Dissociation Rate Constants [V₀]

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Initial Reaction Rate given Catalytic Rate Constant and Dissociation Rate Constants Solution

STEP 0: Pre-Calculation Summary

Formula Used

Initial Reaction Rate = (Catalytic Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/(Dissociation Rate Constant+Substrate Concentration)
V₀ = (k_cat*[E₀]*S)/(K_D+S)
This formula uses 5 Variables

Variables Used

Initial Reaction Rate - (Measured in Mole per Cubic Meter Second) - The Initial Reaction Rate is defined as the initial speed at which a chemical reaction takes place.
Catalytic Rate Constant - (Measured in 1 Per Second) - The Catalytic Rate Constant is defined as the rate constant for conversion of the enzyme-substrate complex to enzyme and product.
Initial Enzyme Concentration - (Measured in Mole per Cubic Meter) - The Initial Enzyme Concentration is defined as the concentration of enzyme at the start of the reaction.
Substrate Concentration - (Measured in Mole per Cubic Meter) - The Substrate Concentration is the number of moles of substrate per liter solution.
Dissociation Rate Constant - (Measured in Mole per Cubic Meter) - The Dissociation Rate Constant is the ratio of reverse and forward rate constant.

STEP 1: Convert Input(s) to Base Unit

Catalytic Rate Constant: 0.65 1 Per Second --> 0.65 1 Per Second No Conversion Required
Initial Enzyme Concentration: 100 Mole per Liter --> 100000 Mole per Cubic Meter (Check conversion here)
Substrate Concentration: 1.5 Mole per Liter --> 1500 Mole per Cubic Meter (Check conversion here)
Dissociation Rate Constant: 5.7 Mole per Liter --> 5700 Mole per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

V₀ = (k_cat*[E₀]*S)/(K_D+S) --> (0.65*100000*1500)/(5700+1500)

Evaluating ... ...

V₀ = 13541.6666666667

STEP 3: Convert Result to Output's Unit

13541.6666666667 Mole per Cubic Meter Second -->13.5416666666667 Mole per Liter Second (Check conversion here)

FINAL ANSWER

13.5416666666667 ≈ 13.54167 Mole per Liter Second <-- Initial Reaction Rate

(Calculation completed in 00.005 seconds)

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< Enzyme Kinetics Calculators

Initial Reaction Rate given Catalytic Rate Constant and Initial Enzyme Concentration

LaTeX Go Initial Reaction Rate = (Catalytic Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/(Michaelis Constant+Substrate Concentration)

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Initial Reaction Rate in Michaelis Menten kinetics Equation

LaTeX Go Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/(Michaelis Constant+Substrate Concentration)

Initial Reaction Rate at Low Substrate Concentration terms of Maximum Rate

LaTeX Go Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/Michaelis Constant

Initial Reaction Rate given Catalytic Rate Constant and Dissociation Rate Constants Formula

LaTeX Go

Initial Reaction Rate = (Catalytic Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/(Dissociation Rate Constant+Substrate Concentration)
V₀ = (k_cat*[E₀]*S)/(K_D+S)

What is Michaelis–Menten kinetics model?

In biochemistry, Michaelis–Menten kinetics is one of the best-known models of enzyme kinetics. Biochemical reactions involving a single substrate are often assumed to follow Michaelis–Menten kinetics, without regard to the model's underlying assumptions. The model takes the form of an equation describing the rate of enzymatic reactions, by relating the reaction rate of formation of product to the concentration of a substrate.

How to Calculate Initial Reaction Rate given Catalytic Rate Constant and Dissociation Rate Constants?

Initial Reaction Rate given Catalytic Rate Constant and Dissociation Rate Constants calculator uses Initial Reaction Rate = (Catalytic Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/(Dissociation Rate Constant+Substrate Concentration) to calculate the Initial Reaction Rate, The Initial reaction rate given catalytic rate constant and dissociation rate constants formula is defined as the relation with the catalytic and dissociation rate constants and with the enzyme and substrate concentration. Initial Reaction Rate is denoted by V₀ symbol.

How to calculate Initial Reaction Rate given Catalytic Rate Constant and Dissociation Rate Constants using this online calculator? To use this online calculator for Initial Reaction Rate given Catalytic Rate Constant and Dissociation Rate Constants, enter Catalytic Rate Constant (k_cat), Initial Enzyme Concentration ([E₀]), Substrate Concentration (S) & Dissociation Rate Constant (K_D) and hit the calculate button. Here is how the Initial Reaction Rate given Catalytic Rate Constant and Dissociation Rate Constants calculation can be explained with given input values -> 0.013542 = (0.65*100000*1500)/(5700+1500).

FAQ

What is Initial Reaction Rate given Catalytic Rate Constant and Dissociation Rate Constants?

The Initial reaction rate given catalytic rate constant and dissociation rate constants formula is defined as the relation with the catalytic and dissociation rate constants and with the enzyme and substrate concentration and is represented as V₀ = (k_cat*[E₀]*S)/(K_D+S) or Initial Reaction Rate = (Catalytic Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/(Dissociation Rate Constant+Substrate Concentration). The Catalytic Rate Constant is defined as the rate constant for conversion of the enzyme-substrate complex to enzyme and product, The Initial Enzyme Concentration is defined as the concentration of enzyme at the start of the reaction, The Substrate Concentration is the number of moles of substrate per liter solution & The Dissociation Rate Constant is the ratio of reverse and forward rate constant.

How to calculate Initial Reaction Rate given Catalytic Rate Constant and Dissociation Rate Constants?

The Initial reaction rate given catalytic rate constant and dissociation rate constants formula is defined as the relation with the catalytic and dissociation rate constants and with the enzyme and substrate concentration is calculated using Initial Reaction Rate = (Catalytic Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/(Dissociation Rate Constant+Substrate Concentration). To calculate Initial Reaction Rate given Catalytic Rate Constant and Dissociation Rate Constants, you need Catalytic Rate Constant (k_cat), Initial Enzyme Concentration ([E₀]), Substrate Concentration (S) & Dissociation Rate Constant (K_D). With our tool, you need to enter the respective value for Catalytic Rate Constant, Initial Enzyme Concentration, Substrate Concentration & Dissociation Rate Constant and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Initial Reaction Rate?

In this formula, Initial Reaction Rate uses Catalytic Rate Constant, Initial Enzyme Concentration, Substrate Concentration & Dissociation Rate Constant. We can use 3 other way(s) to calculate the same, which is/are as follows -

Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/(Michaelis Constant+Substrate Concentration)
Initial Reaction Rate = (Catalytic Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/(Michaelis Constant+Substrate Concentration)
Initial Reaction Rate = (Catalytic Rate Constant*Initial Enzyme Concentration*Substrate Concentration)/Michaelis Constant

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