Initial Reaction Rate in presence of Uncompetitive Inhibitor Calculator

✖The Maximum Rate is defined as the maximum speed achieved by the system at saturated substrate concentration.ⓘ Maximum Rate [V_max]			+10% -10%
✖The Substrate Concentration is the number of moles of substrate per liter solution.ⓘ Substrate Concentration [S]			+10% -10%
✖The Michaelis Constant is numerically equal to the substrate concentration at which the reaction rate is half of the maximum rate of the system.ⓘ Michaelis Constant [K_M]			+10% -10%
✖The Enzyme Substrate Modifying Factor is defined by the inhibitor concentration and the dissociation constant of the enzyme-substrate complex.ⓘ Enzyme Substrate Modifying Factor [α^']			+10% -10%

✖The Initial Reaction Rate is defined as the initial speed at which a chemical reaction takes place.ⓘ Initial Reaction Rate in presence of Uncompetitive Inhibitor [V₀]

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Initial Reaction Rate in presence of Uncompetitive Inhibitor Solution

STEP 0: Pre-Calculation Summary

Formula Used

Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/(Michaelis Constant+(Enzyme Substrate Modifying Factor*Substrate Concentration))
V₀ = (V_max*S)/(K_M+(α^'*S))
This formula uses 5 Variables

Variables Used

Initial Reaction Rate - (Measured in Mole per Cubic Meter Second) - The Initial Reaction Rate is defined as the initial speed at which a chemical reaction takes place.
Maximum Rate - (Measured in Mole per Cubic Meter Second) - The Maximum Rate is defined as the maximum speed achieved by the system at saturated substrate concentration.
Substrate Concentration - (Measured in Mole per Cubic Meter) - The Substrate Concentration is the number of moles of substrate per liter solution.
Michaelis Constant - (Measured in Mole per Cubic Meter) - The Michaelis Constant is numerically equal to the substrate concentration at which the reaction rate is half of the maximum rate of the system.
Enzyme Substrate Modifying Factor - The Enzyme Substrate Modifying Factor is defined by the inhibitor concentration and the dissociation constant of the enzyme-substrate complex.

STEP 1: Convert Input(s) to Base Unit

Maximum Rate: 40 Mole per Liter Second --> 40000 Mole per Cubic Meter Second (Check conversion here)
Substrate Concentration: 1.5 Mole per Liter --> 1500 Mole per Cubic Meter (Check conversion here)
Michaelis Constant: 3 Mole per Liter --> 3000 Mole per Cubic Meter (Check conversion here)
Enzyme Substrate Modifying Factor: 2 --> No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

V₀ = (V_max*S)/(K_M+(α^'*S)) --> (40000*1500)/(3000+(2*1500))

Evaluating ... ...

V₀ = 10000

STEP 3: Convert Result to Output's Unit

10000 Mole per Cubic Meter Second -->10 Mole per Liter Second (Check conversion here)

FINAL ANSWER

10 Mole per Liter Second <-- Initial Reaction Rate

(Calculation completed in 00.004 seconds)

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< Uncompetitive Inhibitor Calculators

Initial Reaction Rate in presence of Uncompetitive Inhibitor

LaTeX Go Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/(Michaelis Constant+(Enzyme Substrate Modifying Factor*Substrate Concentration))

Maximum Reaction Rate in Presence of Uncompetitive Inhibitor

LaTeX Go Maximum Rate = (Initial Reaction Rate*(Michaelis Constant+(Enzyme Substrate Modifying Factor*Substrate Concentration)))/Substrate Concentration

Substrate Concentration in presence of Uncompetitive Inhibitor

LaTeX Go Substrate Concentration = (Michaelis Constant*Initial Reaction Rate)/(Maximum Rate-(Initial Reaction Rate*Enzyme Substrate Modifying Factor))

Michaelis Constant in Presence of Uncompetitive Inhibitor

LaTeX Go Michaelis Constant = (Substrate Concentration*(Maximum Rate-(Initial Reaction Rate*Enzyme Substrate Modifying Factor)))/Initial Reaction Rate

Initial Reaction Rate in presence of Uncompetitive Inhibitor Formula

LaTeX Go

Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/(Michaelis Constant+(Enzyme Substrate Modifying Factor*Substrate Concentration))
V₀ = (V_max*S)/(K_M+(α^'*S))

What is Uncompetitive inhibitor?

Uncompetitive inhibition, also known as anti-competitive inhibition, takes place when an enzyme inhibitor binds only to the complex formed between the enzyme and the substrate (the E-S complex). Uncompetitive inhibition typically occurs in reactions with two or more substrates or products. Uncompetitive inhibition is distinguished from competitive inhibition by two observations: first uncompetitive inhibition cannot be reversed by increasing [S] and second, as shown, the Lineweaver–Burk plot yields parallel rather than intersecting lines.

How to Calculate Initial Reaction Rate in presence of Uncompetitive Inhibitor?

Initial Reaction Rate in presence of Uncompetitive Inhibitor calculator uses Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/(Michaelis Constant+(Enzyme Substrate Modifying Factor*Substrate Concentration)) to calculate the Initial Reaction Rate, The Initial reaction rate in presence of uncompetitive inhibitor formula is defined by the altered Michaelis-Menten equation. Initial Reaction Rate is denoted by V₀ symbol.

How to calculate Initial Reaction Rate in presence of Uncompetitive Inhibitor using this online calculator? To use this online calculator for Initial Reaction Rate in presence of Uncompetitive Inhibitor, enter Maximum Rate (V_max), Substrate Concentration (S), Michaelis Constant (K_M) & Enzyme Substrate Modifying Factor (α^') and hit the calculate button. Here is how the Initial Reaction Rate in presence of Uncompetitive Inhibitor calculation can be explained with given input values -> 0.01 = (40000*1500)/(3000+(2*1500)).

FAQ

What is Initial Reaction Rate in presence of Uncompetitive Inhibitor?

The Initial reaction rate in presence of uncompetitive inhibitor formula is defined by the altered Michaelis-Menten equation and is represented as V₀ = (V_max*S)/(K_M+(α^'*S)) or Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/(Michaelis Constant+(Enzyme Substrate Modifying Factor*Substrate Concentration)). The Maximum Rate is defined as the maximum speed achieved by the system at saturated substrate concentration, The Substrate Concentration is the number of moles of substrate per liter solution, The Michaelis Constant is numerically equal to the substrate concentration at which the reaction rate is half of the maximum rate of the system & The Enzyme Substrate Modifying Factor is defined by the inhibitor concentration and the dissociation constant of the enzyme-substrate complex.

How to calculate Initial Reaction Rate in presence of Uncompetitive Inhibitor?

The Initial reaction rate in presence of uncompetitive inhibitor formula is defined by the altered Michaelis-Menten equation is calculated using Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/(Michaelis Constant+(Enzyme Substrate Modifying Factor*Substrate Concentration)). To calculate Initial Reaction Rate in presence of Uncompetitive Inhibitor, you need Maximum Rate (V_max), Substrate Concentration (S), Michaelis Constant (K_M) & Enzyme Substrate Modifying Factor (α^'). With our tool, you need to enter the respective value for Maximum Rate, Substrate Concentration, Michaelis Constant & Enzyme Substrate Modifying Factor and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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