What is competitive Inhibition?
In competitive inhibition, the substrate and inhibitor cannot bind to the enzyme at the same time, as shown in the figure on the right. This usually results from the inhibitor having an affinity for the active site of an enzyme where the substrate also binds; the substrate and inhibitor compete for access to the enzyme's active site. This type of inhibition can be overcome by sufficiently high concentrations of substrate (Vmax remains constant), i.e., by out-competing the inhibitor. However, the apparent Km will increase as it takes a higher concentration of the substrate to reach the Km point, or half the Vmax. Competitive inhibitors are often similar in structure to the real substrate.
How to Calculate Initial Rate of System given Rate Constant and Enzyme Substrate Complex Concentration?
Initial Rate of System given Rate Constant and Enzyme Substrate Complex Concentration calculator uses Initial Reaction Rate given RC = Final Rate Constant*Enzyme Substrate Complex Concentration to calculate the Initial Reaction Rate given RC, The Initial rate of system given rate constant and enzyme substrate complex concentration formula is defined as the product of rate constant of the reaction converting enzyme-substrate intermediate to the product with the concentration of enzyme-substrate complex. Initial Reaction Rate given RC is denoted by VRC symbol.
How to calculate Initial Rate of System given Rate Constant and Enzyme Substrate Complex Concentration using this online calculator? To use this online calculator for Initial Rate of System given Rate Constant and Enzyme Substrate Complex Concentration, enter Final Rate Constant (k2) & Enzyme Substrate Complex Concentration (ES) and hit the calculate button. Here is how the Initial Rate of System given Rate Constant and Enzyme Substrate Complex Concentration calculation can be explained with given input values -> 0.23 = 23*10000.