Initial Rate given Apparent value of Michaelis Menten Constant Calculator

✖The Maximum Rate is defined as the maximum speed achieved by the system at saturated substrate concentration.ⓘ Maximum Rate [V_max]			+10% -10%
✖The Substrate Concentration is the number of moles of substrate per liter solution.ⓘ Substrate Concentration [S]			+10% -10%
✖The Apparent Michaelis Constant is defined as the Michaelis–Menten constant in the presence of a competitive inhibitor.ⓘ Apparent Michaelis Constant [Km^app]			+10% -10%

✖The Initial Reaction Rate is defined as the initial speed at which a chemical reaction takes place.ⓘ Initial Rate given Apparent value of Michaelis Menten Constant [V₀]

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Initial Rate given Apparent value of Michaelis Menten Constant Solution

STEP 0: Pre-Calculation Summary

Formula Used

Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/(Apparent Michaelis Constant+Substrate Concentration)
V₀ = (V_max*S)/(Km^app+S)
This formula uses 4 Variables

Variables Used

Initial Reaction Rate - (Measured in Mole per Cubic Meter Second) - The Initial Reaction Rate is defined as the initial speed at which a chemical reaction takes place.
Maximum Rate - (Measured in Mole per Cubic Meter Second) - The Maximum Rate is defined as the maximum speed achieved by the system at saturated substrate concentration.
Substrate Concentration - (Measured in Mole per Cubic Meter) - The Substrate Concentration is the number of moles of substrate per liter solution.
Apparent Michaelis Constant - (Measured in Mole per Cubic Meter) - The Apparent Michaelis Constant is defined as the Michaelis–Menten constant in the presence of a competitive inhibitor.

STEP 1: Convert Input(s) to Base Unit

Maximum Rate: 40 Mole per Liter Second --> 40000 Mole per Cubic Meter Second (Check conversion here)
Substrate Concentration: 1.5 Mole per Liter --> 1500 Mole per Cubic Meter (Check conversion here)
Apparent Michaelis Constant: 12 Mole per Liter --> 12000 Mole per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

V₀ = (V_max*S)/(Km^app+S) --> (40000*1500)/(12000+1500)

Evaluating ... ...

V₀ = 4444.44444444444

STEP 3: Convert Result to Output's Unit

4444.44444444444 Mole per Cubic Meter Second -->4.44444444444444 Mole per Liter Second (Check conversion here)

FINAL ANSWER

4.44444444444444 ≈ 4.444444 Mole per Liter Second <-- Initial Reaction Rate

(Calculation completed in 00.004 seconds)

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< Michaelis Menten Kinetics Equation Calculators

Michaelis Constant given Catalytic Rate Constant and Initial Enzyme Concentration

LaTeX Go Michaelis Constant = (Substrate Concentration*((Catalytic Rate Constant*Initial Enzyme Concentration)-Initial Reaction Rate))/Initial Reaction Rate

Maximum Rate of System from Michaelis Menten Kinetics equation

LaTeX Go Maximum Rate = (Initial Reaction Rate*(Michaelis Constant+Substrate Concentration))/Substrate Concentration

Substrate Concentration from Michaelis Menten Kinetics Equation

LaTeX Go Substrate Concentration = (Michaelis Constant*Initial Reaction Rate)/(Maximum Rate-Initial Reaction Rate)

Michaelis Constant from Michaelis Menten kinetics equation

LaTeX Go Michaelis Constant = Substrate Concentration*((Maximum Rate-Initial Reaction Rate)/Initial Reaction Rate)

Initial Rate given Apparent value of Michaelis Menten Constant Formula

LaTeX Go

Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/(Apparent Michaelis Constant+Substrate Concentration)
V₀ = (V_max*S)/(Km^app+S)

What is competitive Inhibition?

In competitive inhibition, the substrate and inhibitor cannot bind to the enzyme at the same time, as shown in the figure on the right. This usually results from the inhibitor having an affinity for the active site of an enzyme where the substrate also binds; the substrate and inhibitor compete for access to the enzyme's active site. This type of inhibition can be overcome by sufficiently high concentrations of substrate (Vmax remains constant), i.e., by out-competing the inhibitor. However, the apparent Km will increase as it takes a higher concentration of the substrate to reach the Km point, or half the Vmax. Competitive inhibitors are often similar in structure to the real substrate.

How to Calculate Initial Rate given Apparent value of Michaelis Menten Constant?

Initial Rate given Apparent value of Michaelis Menten Constant calculator uses Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/(Apparent Michaelis Constant+Substrate Concentration) to calculate the Initial Reaction Rate, The Initial rate given apparent value of Michaelis Menten constant formula is defined as a plot of the reaction velocity (V0) associated with the concentration [S] of the substrate can then be used to determine values such as Vmax, initial velocity, and Km(app). Initial Reaction Rate is denoted by V₀ symbol.

How to calculate Initial Rate given Apparent value of Michaelis Menten Constant using this online calculator? To use this online calculator for Initial Rate given Apparent value of Michaelis Menten Constant, enter Maximum Rate (V_max), Substrate Concentration (S) & Apparent Michaelis Constant (Km^app) and hit the calculate button. Here is how the Initial Rate given Apparent value of Michaelis Menten Constant calculation can be explained with given input values -> 0.004444 = (40000*1500)/(12000+1500).

FAQ

What is Initial Rate given Apparent value of Michaelis Menten Constant?

The Initial rate given apparent value of Michaelis Menten constant formula is defined as a plot of the reaction velocity (V0) associated with the concentration [S] of the substrate can then be used to determine values such as Vmax, initial velocity, and Km(app) and is represented as V₀ = (V_max*S)/(Km^app+S) or Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/(Apparent Michaelis Constant+Substrate Concentration). The Maximum Rate is defined as the maximum speed achieved by the system at saturated substrate concentration, The Substrate Concentration is the number of moles of substrate per liter solution & The Apparent Michaelis Constant is defined as the Michaelis–Menten constant in the presence of a competitive inhibitor.

How to calculate Initial Rate given Apparent value of Michaelis Menten Constant?

The Initial rate given apparent value of Michaelis Menten constant formula is defined as a plot of the reaction velocity (V0) associated with the concentration [S] of the substrate can then be used to determine values such as Vmax, initial velocity, and Km(app) is calculated using Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/(Apparent Michaelis Constant+Substrate Concentration). To calculate Initial Rate given Apparent value of Michaelis Menten Constant, you need Maximum Rate (V_max), Substrate Concentration (S) & Apparent Michaelis Constant (Km^app). With our tool, you need to enter the respective value for Maximum Rate, Substrate Concentration & Apparent Michaelis Constant and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Initial Reaction Rate?

In this formula, Initial Reaction Rate uses Maximum Rate, Substrate Concentration & Apparent Michaelis Constant. We can use 1 other way(s) to calculate the same, which is/are as follows -

Initial Reaction Rate = (Maximum Rate*Substrate Concentration)/((Enzyme Modifying Factor*Michaelis Constant)+(Enzyme Substrate Modifying Factor*Substrate Concentration))

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