Initial Enzyme Concentration given Dissociation Rate Constant Calculator

✖The Enzyme Substrate Complex Concentration is defined as the concentration of intermediate formed from the reaction of enzyme and substrate.ⓘ Enzyme Substrate Complex Concentration [ES]			+10% -10%
✖The Dissociation Rate Constant is the ratio of reverse and forward rate constant.ⓘ Dissociation Rate Constant [K_D]			+10% -10%
✖The Substrate Concentration is the number of moles of substrate per liter solution.ⓘ Substrate Concentration [S]			+10% -10%

✖Enzyme Concentration Initially is defined as the concentration of enzyme at the start of the reaction.ⓘ Initial Enzyme Concentration given Dissociation Rate Constant [[E_initial]]

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Initial Enzyme Concentration given Dissociation Rate Constant Solution

STEP 0: Pre-Calculation Summary

Formula Used

Enzyme Concentration Initially = (Enzyme Substrate Complex Concentration*(Dissociation Rate Constant+Substrate Concentration))/(Substrate Concentration)
[E_initial] = (ES*(K_D+S))/(S)
This formula uses 4 Variables

Variables Used

Enzyme Concentration Initially - (Measured in Mole per Cubic Meter) - Enzyme Concentration Initially is defined as the concentration of enzyme at the start of the reaction.
Enzyme Substrate Complex Concentration - (Measured in Mole per Cubic Meter) - The Enzyme Substrate Complex Concentration is defined as the concentration of intermediate formed from the reaction of enzyme and substrate.
Dissociation Rate Constant - (Measured in Mole per Cubic Meter) - The Dissociation Rate Constant is the ratio of reverse and forward rate constant.
Substrate Concentration - (Measured in Mole per Cubic Meter) - The Substrate Concentration is the number of moles of substrate per liter solution.

STEP 1: Convert Input(s) to Base Unit

Enzyme Substrate Complex Concentration: 10 Mole per Liter --> 10000 Mole per Cubic Meter (Check conversion here)
Dissociation Rate Constant: 5.7 Mole per Liter --> 5700 Mole per Cubic Meter (Check conversion here)
Substrate Concentration: 1.5 Mole per Liter --> 1500 Mole per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

[E_initial] = (ES*(K_D+S))/(S) --> (10000*(5700+1500))/(1500)

Evaluating ... ...

[E_initial] = 48000

STEP 3: Convert Result to Output's Unit

48000 Mole per Cubic Meter -->48 Mole per Liter (Check conversion here)

FINAL ANSWER

48 Mole per Liter <-- Enzyme Concentration Initially

(Calculation completed in 00.004 seconds)

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< Complex Concentration Calculators

Substrate Concentration given Catalytic Rate Constant and Initial Enzyme Concentration

LaTeX Go Concentration of Substrate = (Michaelis Constant*Initial Reaction Rate)/((Catalytic Rate Constant*Initial Enzyme Concentration)-Initial Reaction Rate)

Substrate Concentration if Michaelis Constant is very Large than Substrate Concentration

LaTeX Go Substrate Concentration = (Initial Reaction Rate*Michaelis Constant)/(Catalytic Rate Constant*Initial Enzyme Concentration)

Initial Enzyme Concentration at Low Substrate Concentration

LaTeX Go Initial Enzyme Concentration = (Initial Reaction Rate*Michaelis Constant)/(Catalytic Rate Constant*Substrate Concentration)

Substrate Concentration given Maximum Rate at Low Concentration

LaTeX Go Substrate Concentration = (Initial Reaction Rate*Michaelis Constant)/Maximum Rate

< Important Formulas on Enzyme Kinetics Calculators

Initial Reaction Rate given Dissociation Rate Constant

LaTeX Go Initial Reaction Rate given DRC = (Maximum Rate*Substrate Concentration)/(Dissociation Rate Constant+Substrate Concentration)

Maximum Rate given Dissociation Rate Constant

LaTeX Go Maximum Rate given DRC = (Initial Reaction Rate*(Dissociation Rate Constant+Substrate Concentration))/Substrate Concentration

Modifying Factor of Enzyme Substrate Complex

LaTeX Go Enzyme Substrate Modifying Factor = 1+(Inhibitor Concentration/Enzyme Substrate Dissociation Constant)

Initial Rate of System given Rate Constant and Enzyme Substrate Complex Concentration

LaTeX Go Initial Reaction Rate given RC = Final Rate Constant*Enzyme Substrate Complex Concentration

Initial Enzyme Concentration given Dissociation Rate Constant Formula

LaTeX Go

Enzyme Concentration Initially = (Enzyme Substrate Complex Concentration*(Dissociation Rate Constant+Substrate Concentration))/(Substrate Concentration)
[E_initial] = (ES*(K_D+S))/(S)

What is Michaelis–Menten kinetics model?

In biochemistry, Michaelis–Menten kinetics is one of the best-known models of enzyme kinetics. Biochemical reactions involving a single substrate are often assumed to follow Michaelis–Menten kinetics, without regard to the model's underlying assumptions. The model takes the form of an equation describing the rate of enzymatic reactions, by relating the reaction rate of formation of product to the concentration of a substrate.

How to Calculate Initial Enzyme Concentration given Dissociation Rate Constant?

Initial Enzyme Concentration given Dissociation Rate Constant calculator uses Enzyme Concentration Initially = (Enzyme Substrate Complex Concentration*(Dissociation Rate Constant+Substrate Concentration))/(Substrate Concentration) to calculate the Enzyme Concentration Initially, The Initial enzyme concentration given dissociation rate constant formula is defined as the relation with the dissociation rate constant and the concentration of enzyme and substrate. Enzyme Concentration Initially is denoted by [E_initial] symbol.

How to calculate Initial Enzyme Concentration given Dissociation Rate Constant using this online calculator? To use this online calculator for Initial Enzyme Concentration given Dissociation Rate Constant, enter Enzyme Substrate Complex Concentration (ES), Dissociation Rate Constant (K_D) & Substrate Concentration (S) and hit the calculate button. Here is how the Initial Enzyme Concentration given Dissociation Rate Constant calculation can be explained with given input values -> 0.048 = (10000*(5700+1500))/(1500).

FAQ

What is Initial Enzyme Concentration given Dissociation Rate Constant?

The Initial enzyme concentration given dissociation rate constant formula is defined as the relation with the dissociation rate constant and the concentration of enzyme and substrate and is represented as [E_initial] = (ES*(K_D+S))/(S) or Enzyme Concentration Initially = (Enzyme Substrate Complex Concentration*(Dissociation Rate Constant+Substrate Concentration))/(Substrate Concentration). The Enzyme Substrate Complex Concentration is defined as the concentration of intermediate formed from the reaction of enzyme and substrate, The Dissociation Rate Constant is the ratio of reverse and forward rate constant & The Substrate Concentration is the number of moles of substrate per liter solution.

How to calculate Initial Enzyme Concentration given Dissociation Rate Constant?

The Initial enzyme concentration given dissociation rate constant formula is defined as the relation with the dissociation rate constant and the concentration of enzyme and substrate is calculated using Enzyme Concentration Initially = (Enzyme Substrate Complex Concentration*(Dissociation Rate Constant+Substrate Concentration))/(Substrate Concentration). To calculate Initial Enzyme Concentration given Dissociation Rate Constant, you need Enzyme Substrate Complex Concentration (ES), Dissociation Rate Constant (K_D) & Substrate Concentration (S). With our tool, you need to enter the respective value for Enzyme Substrate Complex Concentration, Dissociation Rate Constant & Substrate Concentration and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Enzyme Concentration Initially?

In this formula, Enzyme Concentration Initially uses Enzyme Substrate Complex Concentration, Dissociation Rate Constant & Substrate Concentration. We can use 2 other way(s) to calculate the same, which is/are as follows -

Enzyme Concentration Initially = (Catalyst Concentration+Enzyme Substrate Complex Concentration+Enzyme Inhibitor Complex Concentration)
Enzyme Concentration Initially = Maximum Rate/Catalytic Rate Constant

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