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Plasma Volume of Drug given Apparent Volume Calculator

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✖The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.ⓘ Volume of Distribution [V_d]			+10% -10%
✖Apparent Tissue Volume is defined as the ratio of the total amount of drug in the body to the concentration of drug in the body tissue.ⓘ Apparent Tissue Volume [V_T]			+10% -10%
✖Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma.ⓘ Fraction Unbound in Plasma [fu]			+10% -10%
✖Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue.ⓘ Fraction Unbound in Tissue [fu_t]			+10% -10%

✖Plasma Volume is the measurement in which a drug is distributed in blood plasma.ⓘ Plasma Volume of Drug given Apparent Volume [V_P]

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Plasma Volume of Drug given Apparent Volume Solution

STEP 0: Pre-Calculation Summary

Formula Used

Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))
V_P = V_d-(V_T*(fu/fu_t))
This formula uses 5 Variables

Variables Used

Plasma Volume - (Measured in Cubic Meter) - Plasma Volume is the measurement in which a drug is distributed in blood plasma.
Volume of Distribution - (Measured in Cubic Meter) - The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.
Apparent Tissue Volume - (Measured in Cubic Meter) - Apparent Tissue Volume is defined as the ratio of the total amount of drug in the body to the concentration of drug in the body tissue.
Fraction Unbound in Plasma - Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma.
Fraction Unbound in Tissue - Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue.

STEP 1: Convert Input(s) to Base Unit

Volume of Distribution: 9 Liter --> 0.009 Cubic Meter (Check conversion here)
Apparent Tissue Volume: 3.5 Liter --> 0.0035 Cubic Meter (Check conversion here)
Fraction Unbound in Plasma: 0.99 --> No Conversion Required
Fraction Unbound in Tissue: 0.7 --> No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

V_P = V_d-(V_T*(fu/fu_t)) --> 0.009-(0.0035*(0.99/0.7))

Evaluating ... ...

V_P = 0.00405

STEP 3: Convert Result to Output's Unit

0.00405 Cubic Meter -->4.05 Liter (Check conversion here)

FINAL ANSWER

4.05 Liter <-- Plasma Volume

(Calculation completed in 00.020 seconds)

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< Plasma Calculators

Apparent Tissue Volume given Plasma Volume and Apparent Volume

LaTeX Go Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma)

Plasma Volume of Drug given Apparent Volume

LaTeX Go Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))

Peak Plasma Concentration Given Peak through Fluctuation

LaTeX Go Peak Plasma Concentration = (Peak Through Fluctuation*Average Plasma Concentration)+Lowest Plasma Concentration

Peak through Fluctuation

LaTeX Go Peak Through Fluctuation = (Peak Plasma Concentration-Lowest Plasma Concentration)/Average Plasma Concentration

Plasma Volume of Drug given Apparent Volume Formula

LaTeX Go

Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))
V_P = V_d-(V_T*(fu/fu_t))

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Plasma Volume of Drug given Apparent Volume?

Plasma Volume of Drug given Apparent Volume calculator uses Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue)) to calculate the Plasma Volume, The Plasma volume of drug given apparent volume formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue. Plasma Volume is denoted by V_P symbol.

How to calculate Plasma Volume of Drug given Apparent Volume using this online calculator? To use this online calculator for Plasma Volume of Drug given Apparent Volume, enter Volume of Distribution (V_d), Apparent Tissue Volume (V_T), Fraction Unbound in Plasma (fu) & Fraction Unbound in Tissue (fu_t) and hit the calculate button. Here is how the Plasma Volume of Drug given Apparent Volume calculation can be explained with given input values -> 4050 = 0.009-(0.0035*(0.99/0.7)).

FAQ

What is Plasma Volume of Drug given Apparent Volume?

The Plasma volume of drug given apparent volume formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue and is represented as V_P = V_d-(V_T*(fu/fu_t)) or Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue)). The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body, Apparent Tissue Volume is defined as the ratio of the total amount of drug in the body to the concentration of drug in the body tissue, Fraction Unbound in Plasma is defined as the systemically available fraction of a drug in blood plasma & Fraction Unbound in Tissue is defined as the systemically available fraction of a drug in body tissue.

How to calculate Plasma Volume of Drug given Apparent Volume?

The Plasma volume of drug given apparent volume formula is defined as the parameter relating drug concentration in plasma to drug amount in the body tissue is calculated using Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue)). To calculate Plasma Volume of Drug given Apparent Volume, you need Volume of Distribution (V_d), Apparent Tissue Volume (V_T), Fraction Unbound in Plasma (fu) & Fraction Unbound in Tissue (fu_t). With our tool, you need to enter the respective value for Volume of Distribution, Apparent Tissue Volume, Fraction Unbound in Plasma & Fraction Unbound in Tissue and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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