What is Pharmacokinetics?
Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.
How to Calculate Fraction of Drug Unbound in Plasma given Plasma Volume?
Fraction of Drug Unbound in Plasma given Plasma Volume calculator uses Fraction Unbound in Plasma = ((Volume of Distribution-Plasma Volume)/Apparent Tissue Volume)*Fraction Unbound in Tissue to calculate the Fraction Unbound in Plasma, The Fraction of drug unbound in plasma given plasma volume formula is defined as the systemically available fraction of a drug in blood plasma with respect to body tissue. Fraction Unbound in Plasma is denoted by fu symbol.
How to calculate Fraction of Drug Unbound in Plasma given Plasma Volume using this online calculator? To use this online calculator for Fraction of Drug Unbound in Plasma given Plasma Volume, enter Volume of Distribution (Vd), Plasma Volume (VP), Apparent Tissue Volume (VT) & Fraction Unbound in Tissue (fut) and hit the calculate button. Here is how the Fraction of Drug Unbound in Plasma given Plasma Volume calculation can be explained with given input values -> 0.8 = ((0.009-0.005)/0.0035)*0.7.