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Effective Dose using Therapeutic Index Calculator

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✖The Median Lethal Dose which represents the dose at which 50% of the population exhibits toxic effects or dies.ⓘ Median Lethal Dose [LD50]			+10% -10%
✖The Therapeutic Index measure that reflects the safety of a drug by comparing its therapeutic dose (effective dose) to its toxic dose.ⓘ Therapeutic Index [TI]			+10% -10%

✖The Median Effective Dose represents the dose at which 50% of the population exhibits the desired therapeutic effect.ⓘ Effective Dose using Therapeutic Index [ED50]

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Effective Dose using Therapeutic Index Solution

STEP 0: Pre-Calculation Summary

Formula Used

Median Effective Dose = Median Lethal Dose/Therapeutic Index
ED50 = LD50/TI
This formula uses 3 Variables

Variables Used

Median Effective Dose - (Measured in Kilogram) - The Median Effective Dose represents the dose at which 50% of the population exhibits the desired therapeutic effect.
Median Lethal Dose - (Measured in Kilogram) - The Median Lethal Dose which represents the dose at which 50% of the population exhibits toxic effects or dies.
Therapeutic Index - The Therapeutic Index measure that reflects the safety of a drug by comparing its therapeutic dose (effective dose) to its toxic dose.

STEP 1: Convert Input(s) to Base Unit

Median Lethal Dose: 150 Milligram --> 0.00015 Kilogram (Check conversion here)
Therapeutic Index: 8 --> No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

ED50 = LD50/TI --> 0.00015/8

Evaluating ... ...

ED50 = 1.875E-05

STEP 3: Convert Result to Output's Unit

1.875E-05 Kilogram -->18.75 Milligram (Check conversion here)

FINAL ANSWER

18.75 Milligram <-- Median Effective Dose

(Calculation completed in 00.004 seconds)

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Created by Ritacheta Sen

University of Calcutta (C.U), Kolkata

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Effective Dose using Therapeutic Index Formula

LaTeX Go

Median Effective Dose = Median Lethal Dose/Therapeutic Index
ED50 = LD50/TI

What is the fate of drugs in body ?

The effect produced by a drug varies with the concentration that is present at its site of action and usually approaches a maximum value beyond which a further increase in concentration is no more effective. A useful measure is the median effective dose, ED50, which is defined as the dose producing a response that is 50 percent of the maximum obtainable. ED50 values provide a useful way of comparing the potencies of drugs that produce physiologically similar effects at different concentrations.

How to Calculate Effective Dose using Therapeutic Index?

Effective Dose using Therapeutic Index calculator uses Median Effective Dose = Median Lethal Dose/Therapeutic Index to calculate the Median Effective Dose, The Effective Dose Using Therapeutic Index formula is defined as the ratio of the dose that produces toxicity to the therapeutic index of the drug. Median Effective Dose is denoted by ED50 symbol.

How to calculate Effective Dose using Therapeutic Index using this online calculator? To use this online calculator for Effective Dose using Therapeutic Index, enter Median Lethal Dose (LD50) & Therapeutic Index (TI) and hit the calculate button. Here is how the Effective Dose using Therapeutic Index calculation can be explained with given input values -> 1.9E+7 = 0.00015/8.

FAQ

What is Effective Dose using Therapeutic Index?

The Effective Dose Using Therapeutic Index formula is defined as the ratio of the dose that produces toxicity to the therapeutic index of the drug and is represented as ED50 = LD50/TI or Median Effective Dose = Median Lethal Dose/Therapeutic Index. The Median Lethal Dose which represents the dose at which 50% of the population exhibits toxic effects or dies & The Therapeutic Index measure that reflects the safety of a drug by comparing its therapeutic dose (effective dose) to its toxic dose.

How to calculate Effective Dose using Therapeutic Index?

The Effective Dose Using Therapeutic Index formula is defined as the ratio of the dose that produces toxicity to the therapeutic index of the drug is calculated using Median Effective Dose = Median Lethal Dose/Therapeutic Index. To calculate Effective Dose using Therapeutic Index, you need Median Lethal Dose (LD50) & Therapeutic Index (TI). With our tool, you need to enter the respective value for Median Lethal Dose & Therapeutic Index and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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