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Dose given volume of distribution and area under curve Calculator

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✖The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.ⓘ Volume of Distribution [V_dis]			+10% -10%
✖Elimination Rate Constant is the rate at which a drug is removed from the body.ⓘ Elimination Rate Constant [k_e]			+10% -10%
✖Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.ⓘ Area Under Curve [AUC]			+10% -10%

✖The Dose is the amount of drug administered.ⓘ Dose given volume of distribution and area under curve [D]

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Dose given volume of distribution and area under curve Solution

STEP 0: Pre-Calculation Summary

Formula Used

Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve
D = V_dis*k_e*AUC
This formula uses 4 Variables

Variables Used

Dose - (Measured in Mole) - The Dose is the amount of drug administered.
Volume of Distribution - (Measured in Cubic Meter) - The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body.
Elimination Rate Constant - (Measured in 1 Per Second) - Elimination Rate Constant is the rate at which a drug is removed from the body.
Area Under Curve - (Measured in Mole Second per Cubic Meter) - Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.

STEP 1: Convert Input(s) to Base Unit

Volume of Distribution: 9 Liter --> 0.009 Cubic Meter (Check conversion here)
Elimination Rate Constant: 0.058 1 Per Hour --> 1.61111111111111E-05 1 Per Second (Check conversion here)
Area Under Curve: 1.32 Mole Second per Liter --> 1320 Mole Second per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

D = V_dis*k_e*AUC --> 0.009*1.61111111111111E-05*1320

Evaluating ... ...

D = 0.0001914

STEP 3: Convert Result to Output's Unit

0.0001914 Mole --> No Conversion Required

FINAL ANSWER

0.0001914 ≈ 0.000191 Mole <-- Dose

(Calculation completed in 00.004 seconds)

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< Dose Calculators

Dose given volume of distribution and area under curve

LaTeX Go Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve

Amount of drug administered given apparent volume

LaTeX Go Dose = Volume of Distribution*Concentration of Drug

Amount of drug in given volume of plasma

LaTeX Go Concentration of Drug = Dose/Volume of Distribution

Amount of drug administered given area under curve

LaTeX Go Dose = Volume of Plasma Cleared*Area Under Curve

Dose given volume of distribution and area under curve Formula

LaTeX Go

Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve
D = V_dis*k_e*AUC

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Dose given volume of distribution and area under curve?

Dose given volume of distribution and area under curve calculator uses Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve to calculate the Dose, Dose given volume of distribution and area under curve formula is defined as the product of the apparent volume in which a drug is distributed with rate at which a drug is removed from the body and area under the curve of concentration-time graph. Dose is denoted by D symbol.

How to calculate Dose given volume of distribution and area under curve using this online calculator? To use this online calculator for Dose given volume of distribution and area under curve, enter Volume of Distribution (V_dis), Elimination Rate Constant (k_e) & Area Under Curve (AUC) and hit the calculate button. Here is how the Dose given volume of distribution and area under curve calculation can be explained with given input values -> 0.000191 = 0.009*1.61111111111111E-05*1320.

FAQ

What is Dose given volume of distribution and area under curve?

Dose given volume of distribution and area under curve formula is defined as the product of the apparent volume in which a drug is distributed with rate at which a drug is removed from the body and area under the curve of concentration-time graph and is represented as D = V_dis*k_e*AUC or Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve. The Volume of Distribution is the parameter relating drug concentration in plasma to drug amount in the body, Elimination Rate Constant is the rate at which a drug is removed from the body & Area under Curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time.

How to calculate Dose given volume of distribution and area under curve?

Dose given volume of distribution and area under curve formula is defined as the product of the apparent volume in which a drug is distributed with rate at which a drug is removed from the body and area under the curve of concentration-time graph is calculated using Dose = Volume of Distribution*Elimination Rate Constant*Area Under Curve. To calculate Dose given volume of distribution and area under curve, you need Volume of Distribution (V_dis), Elimination Rate Constant (k_e) & Area Under Curve (AUC). With our tool, you need to enter the respective value for Volume of Distribution, Elimination Rate Constant & Area Under Curve and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Dose?

In this formula, Dose uses Volume of Distribution, Elimination Rate Constant & Area Under Curve. We can use 2 other way(s) to calculate the same, which is/are as follows -

Dose = Volume of Distribution*Concentration of Drug
Dose = Volume of Plasma Cleared*Area Under Curve

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