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Clearance of Drug given Maintenance Dose Calculator

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✖The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.ⓘ Maintenance Dose [MD]			+10% -10%
✖The Bioavailability of Drug is defined as the systemically available fraction of a drug.ⓘ Bioavailability of Drug [f]			+10% -10%
✖The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.ⓘ Target Plasma Concentration [C_p]			+10% -10%

✖Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.ⓘ Clearance of Drug given Maintenance Dose [CL_drug]

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Clearance of Drug given Maintenance Dose Solution

STEP 0: Pre-Calculation Summary

Formula Used

Drug Clearance = (Maintenance Dose*Bioavailability of Drug)/Target Plasma Concentration
CL_drug = (MD*f)/C_p
This formula uses 4 Variables

Variables Used

Drug Clearance - (Measured in Cubic Meter per Second) - Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.
Maintenance Dose - (Measured in Kilogram per Second) - The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.
Bioavailability of Drug - The Bioavailability of Drug is defined as the systemically available fraction of a drug.
Target Plasma Concentration - (Measured in Kilogram per Cubic Meter) - The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.

STEP 1: Convert Input(s) to Base Unit

Maintenance Dose: 70 Milligram per Hour --> 1.94444444444444E-08 Kilogram per Second (Check conversion here)
Bioavailability of Drug: 9.5 --> No Conversion Required
Target Plasma Concentration: 30 Milligram per Liter --> 0.03 Kilogram per Cubic Meter (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

CL_drug = (MD*f)/C_p --> (1.94444444444444E-08*9.5)/0.03

Evaluating ... ...

CL_drug = 6.15740740740739E-06

STEP 3: Convert Result to Output's Unit

6.15740740740739E-06 Cubic Meter per Second --> No Conversion Required

FINAL ANSWER

6.15740740740739E-06 ≈ 6.2E-6 Cubic Meter per Second <-- Drug Clearance

(Calculation completed in 00.007 seconds)

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Created by Ritacheta Sen

University of Calcutta (C.U), Kolkata

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Clearance of Drug given Maintenance Dose Formula

LaTeX Go

Drug Clearance = (Maintenance Dose*Bioavailability of Drug)/Target Plasma Concentration
CL_drug = (MD*f)/C_p

How does maintenance dose help in therapy ?

Maintenance dose is the maintenance rate [mg/h] of drug administration equal to the rate of elimination at steady state. This is not to be confused with dose regimen, which is a type of drug therapy in which the dose [mg] of a drug is given at a regular dosing interval on a repetitive basis. Continuing the maintenance dose for about 4 to 5 half-lives (t½) of the drug will approximate the steady state level. One or more doses higher than the maintenance dose can be given together at the beginning of therapy with a loading dose.

How to Calculate Clearance of Drug given Maintenance Dose?

Clearance of Drug given Maintenance Dose calculator uses Drug Clearance = (Maintenance Dose*Bioavailability of Drug)/Target Plasma Concentration to calculate the Drug Clearance, The Clearance of Drug given Maintenance Dose formula is defined as ratio of the product of the maintenance dose and bioavailability of drug to the target plasma concentration. Drug Clearance is denoted by CL_drug symbol.

How to calculate Clearance of Drug given Maintenance Dose using this online calculator? To use this online calculator for Clearance of Drug given Maintenance Dose, enter Maintenance Dose (MD), Bioavailability of Drug (f) & Target Plasma Concentration (C_p) and hit the calculate button. Here is how the Clearance of Drug given Maintenance Dose calculation can be explained with given input values -> 6.2E-6 = (1.94444444444444E-08*9.5)/0.03.

FAQ

What is Clearance of Drug given Maintenance Dose?

The Clearance of Drug given Maintenance Dose formula is defined as ratio of the product of the maintenance dose and bioavailability of drug to the target plasma concentration and is represented as CL_drug = (MD*f)/C_p or Drug Clearance = (Maintenance Dose*Bioavailability of Drug)/Target Plasma Concentration. The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration, The Bioavailability of Drug is defined as the systemically available fraction of a drug & The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.

How to calculate Clearance of Drug given Maintenance Dose?

The Clearance of Drug given Maintenance Dose formula is defined as ratio of the product of the maintenance dose and bioavailability of drug to the target plasma concentration is calculated using Drug Clearance = (Maintenance Dose*Bioavailability of Drug)/Target Plasma Concentration. To calculate Clearance of Drug given Maintenance Dose, you need Maintenance Dose (MD), Bioavailability of Drug (f) & Target Plasma Concentration (C_p). With our tool, you need to enter the respective value for Maintenance Dose, Bioavailability of Drug & Target Plasma Concentration and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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