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Bioavailability of Drug given Maintenance Dose Calculator

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✖Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.ⓘ Drug Clearance [CL_drug]			+10% -10%
✖The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.ⓘ Target Plasma Concentration [C_p]			+10% -10%
✖The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.ⓘ Maintenance Dose [MD]			+10% -10%

✖The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.ⓘ Bioavailability of Drug given Maintenance Dose [F%]

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Bioavailability of Drug given Maintenance Dose Solution

STEP 0: Pre-Calculation Summary

Formula Used

Bioavailability Of drug dose = (Drug Clearance*Target Plasma Concentration)/Maintenance Dose
F% = (CL_drug*C_p)/MD
This formula uses 4 Variables

Variables Used

Bioavailability Of drug dose - The Bioavailability Of drug dose is describe the fraction or percentage of administration drug that reaches the systemic circulation in an unchanged and active form.
Drug Clearance - (Measured in Cubic Meter per Second) - Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation.
Target Plasma Concentration - (Measured in Kilogram per Cubic Meter) - The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration.
Maintenance Dose - (Measured in Kilogram per Second) - The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.

STEP 1: Convert Input(s) to Base Unit

Drug Clearance: 2 Cubic Meter per Second --> 2 Cubic Meter per Second No Conversion Required
Target Plasma Concentration: 30 Milligram per Liter --> 0.03 Kilogram per Cubic Meter (Check conversion here)
Maintenance Dose: 70 Milligram per Hour --> 1.94444444444444E-08 Kilogram per Second (Check conversion here)

STEP 2: Evaluate Formula

Substituting Input Values in Formula

F% = (CL_drug*C_p)/MD --> (2*0.03)/1.94444444444444E-08

Evaluating ... ...

F% = 3085714.28571429

STEP 3: Convert Result to Output's Unit

3085714.28571429 --> No Conversion Required

FINAL ANSWER

3085714.28571429 ≈ 3.1E+6 <-- Bioavailability Of drug dose

(Calculation completed in 00.016 seconds)

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Created by Ritacheta Sen

University of Calcutta (C.U), Kolkata

Ritacheta Sen has created this Calculator and 25+ more calculators!

Verified by Soupayan banerjee

National University of Judicial Science (NUJS), Kolkata

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Bioavailability of Drug given Maintenance Dose Formula

LaTeX Go

Bioavailability Of drug dose = (Drug Clearance*Target Plasma Concentration)/Maintenance Dose
F% = (CL_drug*C_p)/MD

What is the bioavailability for intravenous drug?

For an intravenously administered drug, the bioavailability F will equal 1, since the drug is directly introduced to the bloodstream. If the patient requires an oral dose, bioavailability will be less than 1 (depending upon absorption, first pass metabolism etc.), requiring a larger loading dose.

How to Calculate Bioavailability of Drug given Maintenance Dose?

Bioavailability of Drug given Maintenance Dose calculator uses Bioavailability Of drug dose = (Drug Clearance*Target Plasma Concentration)/Maintenance Dose to calculate the Bioavailability Of drug dose, The Bioavailability of Drug given Maintenance Dose formula is defined as the ratio of the product of the clearance of drug and target plasma concentration to the maintenance dose. Bioavailability Of drug dose is denoted by F% symbol.

How to calculate Bioavailability of Drug given Maintenance Dose using this online calculator? To use this online calculator for Bioavailability of Drug given Maintenance Dose, enter Drug Clearance (CL_drug), Target Plasma Concentration (C_p) & Maintenance Dose (MD) and hit the calculate button. Here is how the Bioavailability of Drug given Maintenance Dose calculation can be explained with given input values -> 3.1E+6 = (2*0.03)/1.94444444444444E-08.

FAQ

What is Bioavailability of Drug given Maintenance Dose?

The Bioavailability of Drug given Maintenance Dose formula is defined as the ratio of the product of the clearance of drug and target plasma concentration to the maintenance dose and is represented as F% = (CL_drug*C_p)/MD or Bioavailability Of drug dose = (Drug Clearance*Target Plasma Concentration)/Maintenance Dose. Drug Clearance is the rate at which a drug or its metabolites are removed from the body and systemic circulation, The Target Plasma Concentration is refer to the desired or optimal concentration of a drug in the bloodstream at a specific time after the administration & The Maintenance Dose is the dose of a drug that is administered on a regular basis to maintained a desired plasma concentration.

How to calculate Bioavailability of Drug given Maintenance Dose?

The Bioavailability of Drug given Maintenance Dose formula is defined as the ratio of the product of the clearance of drug and target plasma concentration to the maintenance dose is calculated using Bioavailability Of drug dose = (Drug Clearance*Target Plasma Concentration)/Maintenance Dose. To calculate Bioavailability of Drug given Maintenance Dose, you need Drug Clearance (CL_drug), Target Plasma Concentration (C_p) & Maintenance Dose (MD). With our tool, you need to enter the respective value for Drug Clearance, Target Plasma Concentration & Maintenance Dose and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

How many ways are there to calculate Bioavailability Of drug dose?

In this formula, Bioavailability Of drug dose uses Drug Clearance, Target Plasma Concentration & Maintenance Dose. We can use 1 other way(s) to calculate the same, which is/are as follows -

Bioavailability Of drug dose = (Volume Of Distribution dose*Target Plasma Concentration)/Loading Dose

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