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Bioavailability of Drug Calculator

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Bioavailability Area under curve Dose Drug Content More >>

✖The Area under Curve Non-Intravenous is the integral of the concentration-time curve after a single dose is administered orally.ⓘ Area under Curve Non-Intravenous [AUC_po]			+10% -10%
✖The Dose Intravenous is the amount of drug administered intravenously.ⓘ Dose Intravenous [D_iv]			+10% -10%
✖Area under Curve Intravenous is the integral of the concentration-time curve after a single dose administered intravenous.ⓘ Area under Curve Intravenous [AUC_iv]			+10% -10%
✖The Dose Non-Intravenous is the amount of drug administered orally.ⓘ Dose Non-Intravenous [D_po]			+10% -10%

✖The Bioavailability of Drug is defined as the systemically available fraction of a drug.ⓘ Bioavailability of Drug [f]

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Bioavailability of Drug Solution

STEP 0: Pre-Calculation Summary

Formula Used

Bioavailability of Drug = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Dose Non-Intravenous)
f = (AUC_po*D_iv)/(AUC_iv*D_po)
This formula uses 5 Variables

Variables Used

Bioavailability of Drug - The Bioavailability of Drug is defined as the systemically available fraction of a drug.
Area under Curve Non-Intravenous - (Measured in Mole Second per Cubic Meter) - The Area under Curve Non-Intravenous is the integral of the concentration-time curve after a single dose is administered orally.
Dose Intravenous - (Measured in Mole) - The Dose Intravenous is the amount of drug administered intravenously.
Area under Curve Intravenous - (Measured in Mole Second per Cubic Meter) - Area under Curve Intravenous is the integral of the concentration-time curve after a single dose administered intravenous.
Dose Non-Intravenous - (Measured in Mole) - The Dose Non-Intravenous is the amount of drug administered orally.

STEP 1: Convert Input(s) to Base Unit

Area under Curve Non-Intravenous: 6 Mole Second per Liter --> 6000 Mole Second per Cubic Meter (Check conversion here)
Dose Intravenous: 12 Mole --> 12 Mole No Conversion Required
Area under Curve Intravenous: 11 Mole Second per Liter --> 11000 Mole Second per Cubic Meter (Check conversion here)
Dose Non-Intravenous: 4 Mole --> 4 Mole No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

f = (AUC_po*D_iv)/(AUC_iv*D_po) --> (6000*12)/(11000*4)

Evaluating ... ...

f = 1.63636363636364

STEP 3: Convert Result to Output's Unit

1.63636363636364 --> No Conversion Required

FINAL ANSWER

1.63636363636364 ≈ 1.636364 <-- Bioavailability of Drug

(Calculation completed in 00.020 seconds)

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< Bioavailability Calculators

Bioavailability of Drug

LaTeX Go Bioavailability of Drug = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Dose Non-Intravenous)

Bioavailability given Rate of Administration and Dosing Interval

LaTeX Go Bioavailability = (Drug Rate of Administration*Dosing Interval)/(Administered Dose*Drug Purity)

Bioavailability given Drug Purity

LaTeX Go Bioavailability = Effective Dose/(Drug Purity*Administered Dose)

Bioavailability given Effective and Administrative Dose

LaTeX Go Bioavailability = Effective Dose/Administered Dose

Bioavailability of Drug Formula

LaTeX Go

Bioavailability of Drug = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Dose Non-Intravenous)
f = (AUC_po*D_iv)/(AUC_iv*D_po)

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Bioavailability of Drug?

Bioavailability of Drug calculator uses Bioavailability of Drug = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Dose Non-Intravenous) to calculate the Bioavailability of Drug, The Bioavailability of drug formula is defined as the comparison the bioavailability of the active drug in systemic circulation following non-intravenous administration to the bioavailability of the same drug following intravenous administration. Bioavailability of Drug is denoted by f symbol.

How to calculate Bioavailability of Drug using this online calculator? To use this online calculator for Bioavailability of Drug, enter Area under Curve Non-Intravenous (AUC_po), Dose Intravenous (D_iv), Area under Curve Intravenous (AUC_iv) & Dose Non-Intravenous (D_po) and hit the calculate button. Here is how the Bioavailability of Drug calculation can be explained with given input values -> 1.636364 = (6000*12)/(11000*4).

FAQ

What is Bioavailability of Drug?

The Bioavailability of drug formula is defined as the comparison the bioavailability of the active drug in systemic circulation following non-intravenous administration to the bioavailability of the same drug following intravenous administration and is represented as f = (AUC_po*D_iv)/(AUC_iv*D_po) or Bioavailability of Drug = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Dose Non-Intravenous). The Area under Curve Non-Intravenous is the integral of the concentration-time curve after a single dose is administered orally, The Dose Intravenous is the amount of drug administered intravenously, Area under Curve Intravenous is the integral of the concentration-time curve after a single dose administered intravenous & The Dose Non-Intravenous is the amount of drug administered orally.

How to calculate Bioavailability of Drug?

The Bioavailability of drug formula is defined as the comparison the bioavailability of the active drug in systemic circulation following non-intravenous administration to the bioavailability of the same drug following intravenous administration is calculated using Bioavailability of Drug = (Area under Curve Non-Intravenous*Dose Intravenous)/(Area under Curve Intravenous*Dose Non-Intravenous). To calculate Bioavailability of Drug, you need Area under Curve Non-Intravenous (AUC_po), Dose Intravenous (D_iv), Area under Curve Intravenous (AUC_iv) & Dose Non-Intravenous (D_po). With our tool, you need to enter the respective value for Area under Curve Non-Intravenous, Dose Intravenous, Area under Curve Intravenous & Dose Non-Intravenous and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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