How does pharmacokinetics deal with the drug dose difference ?
In medicine, the treatment for most conditions uses various pharmacological medications. For each of these individual medications, the route of administration, appropriate dosage, and frequency of use are determined by the medication’s pharmacokinetics (PK). Pharmacokinetics is the relationship between an administered dose of a drug and its measured concentration within the body. An individual medication’s PK is governed by how it moves within the body through absorption, bioavailability, distribution, metabolism, and excretion.
The characteristics that define an individual medication’s PK can help determine the loading dose. While a patient takes a specific drug to achieve the therapeutic benefit, the drug must reach a certain steady-state concentration. Typically, for any medication, five to seven half-lives are required for this to be achieved.
How to Calculate Bioavailability of Drug Dose given Loading Dose?
Bioavailability of Drug Dose given Loading Dose calculator uses Bioavailability Of drug dose = (Volume Of Distribution dose*Target Plasma Concentration)/Loading Dose to calculate the Bioavailability Of drug dose, The Bioavailability of Drug Dose given Loading Dose formula is defined as the ratio of the product of the volume of dose distribution and target plasma concentration to the loading dose of drug. Bioavailability Of drug dose is denoted by F% symbol.
How to calculate Bioavailability of Drug Dose given Loading Dose using this online calculator? To use this online calculator for Bioavailability of Drug Dose given Loading Dose, enter Volume Of Distribution dose (Vd), Target Plasma Concentration (Cp) & Loading Dose (LD) and hit the calculate button. Here is how the Bioavailability of Drug Dose given Loading Dose calculation can be explained with given input values -> 1E-6 = (0.05*0.03)/5E-05.