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Average Plasma Concentration given Peak through Fluctuation Calculator

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✖Peak Plasma Concentration is the maximum concentration of a drug after administration.ⓘ Peak Plasma Concentration [C_max]			+10% -10%
✖Lowest Plasma Concentration is the minimum concentration that a drug reaches before the next dose is administered.ⓘ Lowest Plasma Concentration [C_min]			+10% -10%
✖Peak Through Fluctuation is defined as the fluctuation within one dosing interval at a steady state.ⓘ Peak Through Fluctuation [%PTF]			+10% -10%

✖Average Plasma Concentration is the average concentration of the drug after administration and before the next dose is administered.ⓘ Average Plasma Concentration given Peak through Fluctuation [C_av]

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Average Plasma Concentration given Peak through Fluctuation Solution

STEP 0: Pre-Calculation Summary

Formula Used

Average Plasma Concentration = (Peak Plasma Concentration-Lowest Plasma Concentration)/Peak Through Fluctuation
C_av = (C_max-C_min)/%PTF
This formula uses 4 Variables

Variables Used

Average Plasma Concentration - (Measured in Mole per Cubic Meter) - Average Plasma Concentration is the average concentration of the drug after administration and before the next dose is administered.
Peak Plasma Concentration - (Measured in Mole per Cubic Meter) - Peak Plasma Concentration is the maximum concentration of a drug after administration.
Lowest Plasma Concentration - (Measured in Mole per Cubic Meter) - Lowest Plasma Concentration is the minimum concentration that a drug reaches before the next dose is administered.
Peak Through Fluctuation - Peak Through Fluctuation is defined as the fluctuation within one dosing interval at a steady state.

STEP 1: Convert Input(s) to Base Unit

Peak Plasma Concentration: 60.9 Mole per Liter --> 60900 Mole per Cubic Meter (Check conversion here)
Lowest Plasma Concentration: 27.7 Mole per Liter --> 27700 Mole per Cubic Meter (Check conversion here)
Peak Through Fluctuation: 0.4188 --> No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

C_av = (C_max-C_min)/%PTF --> (60900-27700)/0.4188

Evaluating ... ...

C_av = 79274.1165234002

STEP 3: Convert Result to Output's Unit

79274.1165234002 Mole per Cubic Meter -->79.2741165234002 Mole per Liter (Check conversion here)

FINAL ANSWER

79.2741165234002 ≈ 79.27412 Mole per Liter <-- Average Plasma Concentration

(Calculation completed in 00.007 seconds)

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Created by Prashant Singh

K J Somaiya College of science (K J Somaiya), Mumbai

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Peak Plasma Concentration Given Peak through Fluctuation

LaTeX Go Peak Plasma Concentration = (Peak Through Fluctuation*Average Plasma Concentration)+Lowest Plasma Concentration

Peak through Fluctuation

LaTeX Go Peak Through Fluctuation = (Peak Plasma Concentration-Lowest Plasma Concentration)/Average Plasma Concentration

Average Plasma Concentration given Peak through Fluctuation Formula

LaTeX Go

Average Plasma Concentration = (Peak Plasma Concentration-Lowest Plasma Concentration)/Peak Through Fluctuation
C_av = (C_max-C_min)/%PTF

What is Pharmacokinetics?

Pharmacokinetics is a branch of pharmacology dedicated to determine the fate of substances administered to a living organism. The substances of interest include any chemical xenobiotic such as: pharmaceutical drugs, pesticides, food additives, cosmetics, etc. It attempts to analyze chemical metabolism and to discover the fate of a chemical from the moment that it is administered up to the point at which it is completely eliminated from the body. Pharmacokinetics is the study of how an organism affects a drug, whereas pharmacodynamics (PD) is the study of how the drug affects the organism. Both together influence dosing, benefit, and adverse effects, as seen in PK/PD models.

How to Calculate Average Plasma Concentration given Peak through Fluctuation?

Average Plasma Concentration given Peak through Fluctuation calculator uses Average Plasma Concentration = (Peak Plasma Concentration-Lowest Plasma Concentration)/Peak Through Fluctuation to calculate the Average Plasma Concentration, The Average plasma concentration given peak through fluctuation formula is defined as subtraction of minimum plasma concentration from the maximum plasma concentration per peak through fluctuation within one dosing interval at steady state. Average Plasma Concentration is denoted by C_av symbol.

How to calculate Average Plasma Concentration given Peak through Fluctuation using this online calculator? To use this online calculator for Average Plasma Concentration given Peak through Fluctuation, enter Peak Plasma Concentration (C_max), Lowest Plasma Concentration (C_min) & Peak Through Fluctuation (%PTF) and hit the calculate button. Here is how the Average Plasma Concentration given Peak through Fluctuation calculation can be explained with given input values -> 0.079274 = (60900-27700)/0.4188.

FAQ

What is Average Plasma Concentration given Peak through Fluctuation?

The Average plasma concentration given peak through fluctuation formula is defined as subtraction of minimum plasma concentration from the maximum plasma concentration per peak through fluctuation within one dosing interval at steady state and is represented as C_av = (C_max-C_min)/%PTF or Average Plasma Concentration = (Peak Plasma Concentration-Lowest Plasma Concentration)/Peak Through Fluctuation. Peak Plasma Concentration is the maximum concentration of a drug after administration, Lowest Plasma Concentration is the minimum concentration that a drug reaches before the next dose is administered & Peak Through Fluctuation is defined as the fluctuation within one dosing interval at a steady state.

How to calculate Average Plasma Concentration given Peak through Fluctuation?

The Average plasma concentration given peak through fluctuation formula is defined as subtraction of minimum plasma concentration from the maximum plasma concentration per peak through fluctuation within one dosing interval at steady state is calculated using Average Plasma Concentration = (Peak Plasma Concentration-Lowest Plasma Concentration)/Peak Through Fluctuation. To calculate Average Plasma Concentration given Peak through Fluctuation, you need Peak Plasma Concentration (C_max), Lowest Plasma Concentration (C_min) & Peak Through Fluctuation (%PTF). With our tool, you need to enter the respective value for Peak Plasma Concentration, Lowest Plasma Concentration & Peak Through Fluctuation and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

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