HCF calculator

Average Concentration of Plasma at Steady State Calculator

Chemistry Engineering Financial Health More >>

↳

Pharmacokinetics Analytical chemistry Atmospheric Chemistry Atomic structure More >>

⤿

Plasma Area under curve Bioavailability Dose More >>

✖The Dose is the amount of drug administered.ⓘ Dose [D]			+10% -10%
✖The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.ⓘ Volume of Plasma Cleared [CL]			+10% -10%
✖The Dosing Interval is the time between drug dose administrations.ⓘ Dosing Interval [Τ]			+10% -10%

✖Average Concentration of Plasma at Steady State is the amount of a drug in a given volume of blood plasma of the sample.ⓘ Average Concentration of Plasma at Steady State [c̅p_ss]

⎘ Copy

👎

Formula

LaTeX

Reset

👍

Download Plasma Formulas PDF PDF Image

Average Concentration of Plasma at Steady State Solution

STEP 0: Pre-Calculation Summary

Formula Used

Average Concentration of Plasma at Steady State = Dose/(Volume of Plasma Cleared*Dosing Interval)
c̅p_ss = D/(CL*Τ)
This formula uses 4 Variables

Variables Used

Average Concentration of Plasma at Steady State - (Measured in Mole per Cubic Meter) - Average Concentration of Plasma at Steady State is the amount of a drug in a given volume of blood plasma of the sample.
Dose - (Measured in Mole) - The Dose is the amount of drug administered.
Volume of Plasma Cleared - (Measured in Cubic Meter per Second) - The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time.
Dosing Interval - (Measured in Second) - The Dosing Interval is the time between drug dose administrations.

STEP 1: Convert Input(s) to Base Unit

Dose: 8 Mole --> 8 Mole No Conversion Required
Volume of Plasma Cleared: 0.48 Liter per Second --> 0.00048 Cubic Meter per Second (Check conversion here)
Dosing Interval: 44 Second --> 44 Second No Conversion Required

STEP 2: Evaluate Formula

Substituting Input Values in Formula

c̅p_ss = D/(CL*Τ) --> 8/(0.00048*44)

Evaluating ... ...

c̅p_ss = 378.787878787879

STEP 3: Convert Result to Output's Unit

378.787878787879 Mole per Cubic Meter -->0.378787878787879 Mole per Liter (Check conversion here)

FINAL ANSWER

0.378787878787879 ≈ 0.378788 Mole per Liter <-- Average Concentration of Plasma at Steady State

(Calculation completed in 00.006 seconds)

You are here -

Home » Chemistry » Pharmacokinetics » Plasma » Average Concentration of Plasma at Steady State

Credits

Created by Soupayan banerjee

National University of Judicial Science (NUJS), Kolkata

Soupayan banerjee has created this Calculator and 200+ more calculators!

Verified by Prerana Bakli

University of Hawaiʻi at Mānoa (UH Manoa), Hawaii, USA

Prerana Bakli has verified this Calculator and 1600+ more calculators!

< Plasma Calculators

Apparent Tissue Volume given Plasma Volume and Apparent Volume

LaTeX Go Apparent Tissue Volume = (Volume of Distribution-Plasma Volume)*(Fraction Unbound in Tissue/Fraction Unbound in Plasma)

Plasma Volume of Drug given Apparent Volume

LaTeX Go Plasma Volume = Volume of Distribution-(Apparent Tissue Volume*(Fraction Unbound in Plasma/Fraction Unbound in Tissue))

Peak Plasma Concentration Given Peak through Fluctuation

LaTeX Go Peak Plasma Concentration = (Peak Through Fluctuation*Average Plasma Concentration)+Lowest Plasma Concentration

Peak through Fluctuation

LaTeX Go Peak Through Fluctuation = (Peak Plasma Concentration-Lowest Plasma Concentration)/Average Plasma Concentration

Average Concentration of Plasma at Steady State Formula

LaTeX Go

Average Concentration of Plasma at Steady State = Dose/(Volume of Plasma Cleared*Dosing Interval)
c̅p_ss = D/(CL*Τ)

What is Pharmacokinetics?

Pharmacokinetics is currently defined as the study of the time course of drug absorption, distribution, metabolism, and excretion. Clinical pharmacokinetics is the application of pharmacokinetic principles to the safe and effective therapeutic management of drugs in an individual patient.

How to Calculate Average Concentration of Plasma at Steady State?

Average Concentration of Plasma at Steady State calculator uses Average Concentration of Plasma at Steady State = Dose/(Volume of Plasma Cleared*Dosing Interval) to calculate the Average Concentration of Plasma at Steady State, The Average Concentration of Plasma at Steady State formula is defined as the concentration of an agent in the plasma which is derived from full blood. Plasma concentrations are used to define major PK and PK/PD parameters. Average Concentration of Plasma at Steady State is denoted by c̅p_ss symbol.

How to calculate Average Concentration of Plasma at Steady State using this online calculator? To use this online calculator for Average Concentration of Plasma at Steady State, enter Dose (D), Volume of Plasma Cleared (CL) & Dosing Interval (Τ) and hit the calculate button. Here is how the Average Concentration of Plasma at Steady State calculation can be explained with given input values -> 0.000379 = 8/(0.00048*44).

FAQ

What is Average Concentration of Plasma at Steady State?

The Average Concentration of Plasma at Steady State formula is defined as the concentration of an agent in the plasma which is derived from full blood. Plasma concentrations are used to define major PK and PK/PD parameters and is represented as c̅p_ss = D/(CL*Τ) or Average Concentration of Plasma at Steady State = Dose/(Volume of Plasma Cleared*Dosing Interval). The Dose is the amount of drug administered, The Volume of Plasma Cleared is defined as the amount of plasma cleared of the drug per unit of time & The Dosing Interval is the time between drug dose administrations.

How to calculate Average Concentration of Plasma at Steady State?

The Average Concentration of Plasma at Steady State formula is defined as the concentration of an agent in the plasma which is derived from full blood. Plasma concentrations are used to define major PK and PK/PD parameters is calculated using Average Concentration of Plasma at Steady State = Dose/(Volume of Plasma Cleared*Dosing Interval). To calculate Average Concentration of Plasma at Steady State, you need Dose (D), Volume of Plasma Cleared (CL) & Dosing Interval (Τ). With our tool, you need to enter the respective value for Dose, Volume of Plasma Cleared & Dosing Interval and hit the calculate button. You can also select the units (if any) for Input(s) and the Output as well.

Home

FREE PDFs

🔍 Search